Though there are no dogs that die, there is discussion in season 5 of parents that are dead dogs

four horses, two dogs, a cat, a babybird, and other animals die or have told of their death

There are non-sentient chickens that are being farmed for food. One episode centres this concept.

But there is a joke referencing it in a flashback scene when Mr. Peanutbutter and Jessica Biel are at a Starbucks in the 2000's.

There are anthropomorphic bugs.

A horse commits suicide by jumping off a bridge onscreen. Multiple members of Bojack's family (father, uncle, grandparents) have died offscreen before the series starts.

One of the minor characters is a black widow spider.

Princess Carolyn's mother and father died offscreen before the start of the series.

There are anthropomorphic snakes.

Drugs are regularly seen being used by the main character and another character dies from an overdose.

BoJack is an alcoholic and Sarah Lynn is a drug addict

The main character is an alcoholic

S1E3: A lemur is on fire, though it's not clear if he died or not. S4E7: A man is lit on fire, and another character is nearly burned at the stake.

S1E11: BoJack's arm is cut by Todd.

S1E5: Diane's brother rips out a tooth trying to open a beer with his mouth.

S4E7: Someone's hands are crushed by falling debris.

S1E12: A character is heard falling, and another character says he broke nearly every bone in his body. S3E5: Diane trips, and her forearm bends at a wild angle. S3E11: Diane breaks her arm again. S4E7: Someone's hands are crushed by falling debris.

S1E11: BoJack hallucinates Diane's eye becoming enlarged and popping.

BoJack's dad died of a head injury. This is only described not shown, in S5E6.

S1:E1 2 Characters are interrogated by what is assumed to be the Cartel, and one is shot and killed on screen

S1E5: Diane learns her dad has died. He is shown discolored and sitting limply in an armchair. S1E11: BoJack stands at his mom's grave in a hallucination. S4E5: There's a flashback to the drive to the funeral of BoJack's dad. S4E11: A brief still of Beatrice at her dad's funeral. S5E5: Princess Carolyn thinks and talks about her dead mom. S5E6: BoJack speaks at his mom's funeral. S5E7: Mr. Peanutbutter realizes his parents did not really go off to a farm when they got old.

There are scenes of a war-torn country, where there are many injured children. Children die in an explosion, but their deaths are not shown.

S2E3: Mentions of somebody's parents divorcing due to BoJack sleeping with the wife. S2E11: Charlotte is married but kisses BoJack and then tells him to leave. S2E12: Rutabaga, who was sleeping with Princess Carolyn while he was supposedly divorcing his wife, reveals that he has rekindled his relationship with his wife. S5E10: Diane invites Mr. Peanutbutter into her apartment. S5E12: It's confirmed that Diane and Mr. Peanutbutter had sex despite him dating Pickles. The two have sex again. This gets discussed in season 6.

S1E1 has a flashback where a character is held hostage by drug lords. S2E6 has a brief joke about a TV host getting kidnapped.

S6E15: BoJack has a dream involving many of his dead friends/family members.

A major subplot of Season 4 involves clown dentists.

S3E11: During a bender, BoJack shows up at the college of the girl he almost slept with when she was 17, and she is clearly distraught.

Several episodes with scenes in the shower/bath (no frontal nudity).

A character throws up for an extended period of time in the first episode, but only cotton candy comes out. In season 4, several characters throw up because they are pregnant, one of whom throws up into someone else's face.

Noteworthy that a minor character (only shown in flashbacks) is lobotomized for "hysteria."

Season 6 has numerous scenes in a rehab center. Noteworthy that S4E1 features a flashback of BoJack's grieving grandmother who is lobotomized for "hysteria."

S1E1: BoJack goes to the hospital for what turns out to be an anxiety attack. He is depicted dying, but it's revealed this is a clip from the sitcom he starred in. S1E7: A very brief clip of BoJack in a full body cast. S1E12: A minor character is seen in lots of casts. S2E11: A teenager gets alcohol poisoning and is seen outside the hospital. S3E5: Diane has to get a cast. S3E7: Someone is seen after delivering her babies. S3E10: Someone is seen resting after surgery. S4E8: Someone is seen resting after a transplant. S4E10: Someone is hospitalized due to an overdose. S4E11: Childbirth. S5E5: BoJack is injured in a fall. S5E9: Post-childbirth. S5E12: Childbirth. S6E6: In a waiting room. S6E14: Todd’s mom is hospitalized for potential cardiac arrest but actually had a panic attack. S6E16: BoJack is briefly seen in the hospital.

Can't recall the specifics regarding medical needles, though drug use is a major theme, but there's a running gag in season 6 about people getting stabbed by a baby porcupine's needles, and the resulting stab wounds are at one point mistaken for drug needles.

It's revealed early on that BoJack's former friend Herb has cancer and a few months left to live. S1E8 involves BoJack visiting Herb, who is receiving medical treatment from home. S2E3 depicts Herb's funeral. He was in remission at the time he died, but the episode involves discussion of cancer.

There's a flashback of a character committing suicide by jumping off a bridge.

S1E1: BoJack has two anxiety attacks. S4E10: BoJack is shown lying on the floor panicking. S6E8: Hollyhock has an anxiety attack at a party but grounds herself. S6E14: Todd’s mom has an anxiety attack.

There is lots of discussion of body image in season 4, including implications about eating disorders.

In Time's Arrow, a lot of that comes from Beatrice's father.

Frequent depiction of using alcohol, drugs, and sex in self-destructive manners. S1E3: Sarah Lynn stabs herself. S5E9: Experiencing withdrawal, BoJack drives into traffic in order to injure himself and get access to more painkillers.

S4E6: A character is heard trapped inside a crate.

There is discussion of body image in season 4.

The title sequence for seasons 1 and 3 contains several seconds of harsh camera flashes. S3E10: BoJack throws a party that has strobelights (4:00-7:30). S4E10: Light strobe effect (intermittently 0:00-1:40). S5E12: Several seconds of dim but rapid strobe right after the title sequence. S6E13: Dim but fast strobe effect for several seconds (24:30).

Some mild documentary-style handheld cam during the cop scenes in S2E5.

S3E4: A seahorse gives birth on a bus. S3E7: Mention of a character going into labor. She's later seen with babies. S4E3: A still is shown post-childbirth. S4E11: Henrietta and Beatrice give birth. S5E12: Sadie gives birth.

Whole storyline about abortions in season 3, including a funny but off-color pop song on the subject.

There is a lot of discussion about miscarriages and abortion.

S2E9: In Princess Carolyn's fantasy, Vanessa Gekko mentions her life falling apart and her children marrying one another. S5E5: A woman jokes about sleeping with her cousins.

[SPOILERS] S2E3: It is implied that Sarah Lynn was sexually abused, though nothing is depicted. S2E11: BoJack nearly has sex with a seventeen-year-old girl, though the girl's mother catches them and puts a stop to it just as they're starting to undress. In a later episode when the girl sees BoJack again, she's clearly made anxious by his presence. S3E6: Anna assaults BoJack. S4E5: There are a few depictions of sexual harassment. S4E10: Mentions of a pedophile molesting children. S5E1: Flip attempts to pull off BoJack's robe, insisting he be naked on camera. S5E4: Significant discussion of misogyny and sexual harassment.

Several sex scenes (no frontal nudity) throughout the series. S2E6 involves lots of discussion of auto-erotic asphyxiation. S3E3 has scenes at a strip club. Season 5 features a sex robot built with dildos/buttplugs that uses lots of dirty phrases.

Throughout season 4, BoJack's senile mother mistakes him for a woman named Henrietta. However, this is not malicious and the misgendering is not the main issue.

In S1E8 a group of protestors are shown with homophobic signs. There's also misogynistic comments in episodes like S2E7 and S4E5. S4E2 mentions Nazis and a character blames Jewish people for WW2. Beatrice sometimes makes outdated comments about gay people and immigrants. S4E5 also has a minor character make racist comments while hitting on Diane. A character in S5E4 makes comments about many different groups (Jewish people, Swedish people, women, etc) but not very graphic and it is exaggerated to being cartoonish.

A character yells "I hate Jews" and is forgiven because his a celebrity. The entire episode is about this kind of injust treatment reserved to celebrities and the normalization of their behaviors.

The first death in the show is Diane's father.

Spoiler: Bojack's old friend Herb has cancer. He is gay and he dies.

S4E2 and S4E11: A character in the 1940's suffers suicidal depression after losing her son and is lobotomized due to her "hysteria;" said lobotomy is used to threaten her daughter into repressing her own emotions.

S2E4: a character is made fun of for her weight gain, and it's later said in S3E11 that fat jokes prompted her to develop an eating disorder. S4E8: Hollyhock is insecure about her weight and BoJack makes insensitive comments about it. S4E11: A young Beatrice is mocked for being fat. There are some other discussions of weight but most of it is played seriously, and most characters who make fat jokes, including the above, are shown in a poor light.

In the Christmas special, Bojack's character admits that Santa is a lie in a way that is phrased like denying the existence of God.

This question is a bit obscure for TV shows. The show has not ended but many of the episodes have very depressing endings, especially the 11th episode of every season.

[SPOILERS] S2E1: BoJack's parents smash plates and yell at one another. S4E1: In a flashback, BoJack's grandfather smashes a glass and yells at his wife for what is clearly untreated grief. She is deemed hysterical and lobotomized. S4E5: BoJack's mom makes a joke about being hit by her husband. S4E11: Beatrice's father demeans his grieving, lobotomized wife for being a "bad mother." S5E4: Mention of a husband choking his wife. S5E11: BoJack punches a wall and chokes Gina, who clearly suffers from PTSD symptoms afterwards.

S1E1: A man is shot, and Todd gets sprayed with blood. S1E3: Sarah Lynn stabs herself. S1E6: A man gets stabbed numerous times. S1E11: There are large blood smears in BoJack's house. BoJack hallucinates Diane becoming seriously deformed and growing all kinds of extra body parts. S2E5: There's a chicken slaughterhouse with bloody axes. S2E9: A character gets shot in the arms. S3E7: Several people are shot. S4E1: Two characters get some pretty deep cuts due to a car crash. S5E1: BoJack gets covered in fake blood. S5E7: Lots of fake blood on a TV set. S5E9: Fake blood on TV set. S6E5: An actress has a fake rod jammed through her abdomen for a TV show. S6E15: Blood pours from a bullet wound in someone’s head.

S2E4: BoJack hits a deer. S3E6: BoJack hits a minor character. S3E10: Someone is hit by a bus. S3E11: BoJack hits a pedestrian.

A whole group of people is buried in S4E7, but they escape in the end (after more than a week)

S5E11: A nuclear missile hits LA on a TV show.

Mr Peanutbutter's agent hangs himself and so does an minor character at the end of the same episode because of auto-erotic asphyxiation

Young Bojack is emotionally abused in several flashbacks, and hit by his father on at least one occasion. A teenage Diane is also shown to be emotionally abused by her family. In S4E10 it is revealed someone has been drugging a teenager without her consent throughout the season, to the point that she passes out. In S5E4 we hear audio of a father verbally abusing and threatening his daughter. In S6E13 the same father verbally abuses her at her college.

S1E1: A man is seen falling from a building with no indication if he survived or not. S1E4: A mother bird discusses pushing her baby out of the nest too early. S1E12: Secretariat jumps off a bridge. S2E7: A man preparing to parachute from a burning plane is knocked out, and it's unclear if he was able to pull the cord or not. S6E15: Several characters fall into darkness in a dream. One character reads a poem describing his thoughts while falling from a bridge in his suicide.

S1E1: Someone is shot and killed. S1E8: Todd is carjacked at gunpoint, but the gun is never fired. S1E9: A woman points an AK-47 during a staged bank robbery. S1E11: BoJack and Todd have guns and fire them in a hallucination. S2E1: A minor character is shown in a war zone. S2E9: Police exchange fire with a woman breaking into a gallery. S3E7: A flashback to the gallery shoot-out, where several people are shot. S4E5: The episode contains discussions of mass shootings and gun legislation. S5E7: Lots of shooting in a TV show.

S1E11: BoJack imagines a hypothetical death where he lets himself drown. S3E10: Stills in a flashback show a character almost drowning. BoJack nearly drowns but is revived. S3E12: A few people drown. S4E1: BoJack and a minor character almost drown. S4E7: Many characters are trapped in a space filling with water and almost drown. S6E15: BoJack is shown dead in a pool.

S1E1: A car crash is heard and a flaming tire rolls across the screen. S2E3: Mentions of Herb being in a car crash. S2E4: Princess Carolyn drives recklessly and causes other cars to crash. S2E5: BoJack drives recklessly and causes other cars to crash. S2E6: BoJack causes a crash off screen. S2E11: Penny crashes into a sign. S3E8: A character driving recklessly is heard crashing. S3E10: A flashback shows a character swerving off the road into a lake. S3E11: BoJack drives under the influence and causes crashes. S4E1: Two characters in a flashback crash. S4E6: BoJack hits two parked cars. S5E9: BoJack drives into oncoming traffic. S6E5: A fake car wreck is set up on a TV set. No crash is shown.

S1E6: A helicopter crashes, and it's unclear if the pilot survives. S2E7: A burning plane is shown coming down but is not shown/heard crashing. A character parachutes out of the plane.

there is a scene in season 5 where a character is strangled but survives. this is a major plot point going forward.