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Here's a disease you don't want to get, even if it is easy to treat. It's coz your doc will probably misdiagnose youhttps://goo.gl/kC7kHs
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PriyankaPulla Retweeted
I think we're both arguing for the same side if you consider this a debate. It is very easy to chose thresholds that demonstrate a particular result so best to publish some form of sensitivity analysis alongside to show how a different threshold would perform.
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PriyankaPulla Retweeted
Layer 2 is related to but distinct from layer 1. Try your best to be the one who finds the limitations or flaws in your findings and esp interpretations, before anyone else does. Fix flaws / limitations if you can; highlight them in Discussion if you can'thttp://bostonreview.net/science-nature/marc-lipsitch-good-science-good-science …
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PriyankaPulla Retweeted
How many examples don’t we have of drugs we knew was safe in one situation, turning out to be harmful in another? Thalidomide in pregnancy, sodium channel blockers in myocardial infarction, and certainly aspirin in kids with viral infections.
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PriyankaPulla Retweeted
Respectfully Prof Mande, do you think we have such actions and mechanisms for Indian journals like IJMR. The journal just published a case control study from ICMR with senior ICMR leadership as co authors. And no COI statement? Is that acceptable?
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PriyankaPulla Retweeted
A novel virus pandemic is THE time for an expedited RCT *No existing evidence *Quick recruitment (Pandemic, duh!) *Survival at d28 is all that matters- no fancy tests or followup *Could have been completed quickly with reliable results- as
#RECOVERY trial just did If only!pic.twitter.com/jGtVoO1xaRThanks. Twitter will use this to make your timeline better. UndoUndo -
Retweeting again, because I find that a lot of people have not even considered the idea that the beginning of a pandemic may be an excellent time to launch RCTs stat. If you can hand over unproven drug to thousands of people, why can't you do an RCT?https://twitter.com/VPrasadMDMPH/status/1268967197226893312 …
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Even seroprevalence can be tricky, but atleast you are not giving a diagnosis to an individual, telling them they are immune, when they may not be
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My understanding is that antibody testing is currently only good for seroprevalence. Too many false positives to give a meaningful result to individuals. Thoughts anyone?https://twitter.com/sumanthraman/status/1268948765336956929 …
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If
@ThePrintIndia was so interested in good science, it wouldn't write gushing, one-sided stories about India's HCQ policy without even bothering to talk to good scientists for an alternative view. Here is the alternative view: https://twitter.com/AnantBhan/status/1269104086265274368?s=20 …https://twitter.com/ShekharGupta/status/1268862192738201602 …Thanks. Twitter will use this to make your timeline better. UndoUndo -
A voice of sanity in a sea of confusionhttps://twitter.com/AnantBhan/status/1269104086265274368 …
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PriyankaPulla Retweeted
16. We have some useful data on Lopinivir ritonivir, HCQ, remdesivir... now there are just dozens of drugs docs are giving that we await data for Toci Azithro/ CAP Abx Full dose anticoag TPA Good thing we aren't making all the same errors there Cheers!
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PriyankaPulla Retweeted
15. Please do not say RCTs not possible, if you personally give (or preside over an institution that gives) an experimental treatment to 5000 people *cough* jacc letter *cough*
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PriyankaPulla Retweeted
13. Use PCR to document outcomes and not self report (ideally budget will permit this) 14. Power trials for REALISTIC effect sizes, not "oh god, wouldn't it be lovely if" effect sizes
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PriyankaPulla Retweeted
10. No one should say the word parachute, unless a drug has a 99.9999% mortality benefit in 10 minutes 11. No one should ever talk about the putative molecular action of an agent in the lay press until RCT is positive 12. If a disease is lethal, consider mortality as the endpt
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PriyankaPulla Retweeted
7 Trials should use bias resistant endpoints and blinding 8 Trials should have a control arm, not test 2 durations of an experimental drug 9. Trials should be adequately powered (and will be with minimal off protocol use)
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PriyankaPulla Retweeted
4. Docs in France should not report 1000 person uncontrolled experiences and denigrate RCTs 5 Politicians should remain quiet 6 No researcher should waste time with retrospective obs studies
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Everyone read this threadhttps://twitter.com/VPrasadMDMPH/status/1268967197226893312 …
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PriyankaPulla Retweeted
First results from the
#RECOVERYTRIAL are in. Hydroxycholoquine does not benefit hospitalised patients with#covid-19. "This is not a treatment for covid," say@PeterHorby and@MartinLandrayThanks. Twitter will use this to make your timeline better. UndoUndo
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