Spyro (series)

Spyro is a series of platform games which primarily features the protagonist Spyro the Dragon and his friend, Sparx the Dragonfly. Since its introduction in 1998, there has been a complete reboot to the series called The Legend of Spyro trilogy, making it a total of ten Spyro games and three Legend of Spyro games. The Spyro series has sold more than 20 million units worldwide. After The Legend of Spyro series concluded, a spin-off franchise under the name of Skylanders was made where Spyro and other related characters were included in.

Games

Spyro the Dragon

Spyro the Dragon was first released in North America on 11 September 1998, for the PlayStation. It was released in Europe on 23 October 1998, In Australia on 15 November 1998 and in Japan on 1 April 1999. It is a platform game that placed the player as Spyro, a small, purple dragon set with the task of freeing his fellow dragons from crystal prisons, which are scattered around their world. Each level is accessed through 'portals' from a main world. The game concludes with a fight between Spyro and the primary antagonist, Gnasty Gnorc. The game sold well, most critics giving it favorable reviews. It also received acclaim for its musical score by Stewart Copeland.

Hunter (2015 film)

Hunter is a 2015 film directed by Gregory Hatanaka and starring Ron Becks with Magda Marcella, Kristine DeBell, George Lazenby and Laurene Landon. It follows the exploits of a veteran cop who must hunt down a cop killer as well as a female teenage serial killer.

Cast

External links

Watcher (Highlander)

Watchers is a secret organization that watches the Immortals in Highlander: The Series and all subsequent related series and movies.

They were introduced in the season 1 finale as a cliffhanger for the subsequent season. Since then, they became an integral part of the series and Duncan MacLeod's adventures.

Appearances

In "The Watchers", Joe Dawson explains the purpose of the Watchers to Duncan MacLeod: "For as long as your kind's been around, we've been watching ... We observe, we record, but we never interfere... Too much of man's history has been lost. When you get through all of life's crap, the only thing that matters is the truth. We want the truth about Immortals to survive, not a bunch of old wives' tales... If we had revealed your secret in more superstitious times, you can imagine the witch hunts... And today... You'd probably end up on page three in one of those supermarket rags next to the two-headed monkey and I'd've been in a straight jacket."

The Watchers is a secret society of mortal humans that observes the lives of the Immortals without revealing themselves. While the Watchers seem to have the resources to function independently, there are Watchers like Joe Dawson who run their own businesses to provide a cover as well as income. Each Immortal is assigned a Watcher whose sole job is to monitor and record daily activities. The network of Watchers generally keeps careful tabs on subjects and tracks even the casual movements of the Immortals. Most Immortals are unaware of the Watchers. The organization was created by Ammaletu, the Akkadian, after he saw Gilgamesh coming back to life. In early episodes all Watchers wore a medallion of the symbol of their organization. In later episodes, each Watcher has the symbol tattooed on the inner wrist.

OMA1

Metalloendopeptidase OMA1, mitochondrial is an enzyme that in humans is encoded by the OMA1 gene. As a Metalloprotease, this protein is a substantial component of the quality control system in the inner membrane of mitochondria. Being activated by enzyme Bax and Bak, mitochondrial protease OMA1 promotes cytochrome c release which subsequently induces apoptosis.

Structure

Gene

The gene OMA1 encodes a metalloprotease, a founding member of a conserved family of membrane-embedded metallopeptidases in mitochondria. The human gene has 9 exons and locates at chromosome band 1p32.2-p32.1

Protein

The human protein Metalloendopetidase OMA1, mitochondrial is 60 kDa in size and composed of 524 amino acids. The peptide fragment 1-13 is mitochondrial transition peptide, the mature protein has a theoretical PI of 9.35.

Function

The inner membrane of mitochondrial houses two AAA proteases and these membrane-embedded peptidases were termed m- and i-AAA proteases to indicate their different topology in the inner membrane. The m-AAA protease is facing the matrix and the i-AAA protease is facing the intermembrane space. OMA1 was shown to share an overlapping proteolytic activity with m-AAA protease. However, OMA1 doesn't completely regulate the turnover of a model substrate, Oxa1, as what the m-AAA protease does. On the contrary, Oma1 only generates N- and C-terminal proteolytic fragments. Recent study showed that the mammalian mitochondrial inner membrane fusion protein OPA1 can be degraded by OMA1 when mitochondria lose membrane potential or adenosine triphosphate. Such inducible proteolysis acts as a regulatory mechanism to proteolytically inactivate of OPA1, thus preventing the fusion of the mitochondrial network.

Nil

Nil is a word commonly used to mean not in list or zero; it is one of several names for the number 0.

Nil may also refer to:

Given names

Surname

Places

NIL (programming language)

NIL was a 32-bit implementation of Lisp developed at MIT and intended to be the successor to Maclisp. NIL stood for "New Implementation of LISP", and was in part a response to DECs VAX computer. The project was headed by Jon L White, with a stated goal of maintaining compatibility with MacLisp whilst fixing many of the problems with the language.

History

The Lisp language was invented in 1958 by John McCarthy while he was at MIT. From its inception, Lisp was closely connected with the artificial intelligence research community, especially on PDP-10 systems. Lisp was used as the implementation of the programming language Micro Planner that was the foundation for the famous AI system SHRDLU. Lisp, in particular Maclisp (so called because it originated at MIT's project MAC) was also used to implement the Macsyma computer algebra system. In the 1970s, as AI research spawned commercial offshoots, the performance of existing Lisp systems became a growing issue.

Partly because of garbage collection (Lisp would use stop-and-copy garbage collection of its single heap for memory allocation) and partly because of its representation of internal structures, Lisp became difficult to run on the memory-limited stock hardware of the day. This led to the creation of LISP machines: dedicated hardware for running Lisp environments and programs. An alternative was to use the more powerful commodity hardware which was becoming available, in particular the DEC VAX.