Crying

Crying is the shedding of tears in response to an emotional state. The act of crying has been defined as "a complex secretomotor phenomenon characterized by the shedding of tears from the lacrimal apparatus, without any irritation of the ocular structures". A related medical term is lacrimation, which also refers to non-emotional shedding of tears. Crying is also known as weeping, wailing, whimpering, and bawling.

For crying to be described as sobbing, it usually has to be accompanied by a set of other symptoms, such as slow but erratic inhalation, occasional instances of breath holding and muscular tremor.

A neuronal connection between the lacrimal gland (tear duct) and the areas of the human brain involved with emotion has been established. There is debate among scientists over whether or not humans are the only animals that produce tears in response to emotional states.Charles Darwin wrote in The Expression of the Emotions in Man and Animals that the keepers of Indian elephants in the London Zoo told him that their charges shed tears in sorrow.

Cry (LL Cool J song)

"Cry" is a single by LL Cool J from his twelfth studio album, Exit 13 (2008). The song features guest vocals by R&B singer Lil' Mo and production by Andreas "Raw Uncut" Dombrowski. The song is noted for its sampling of Bunny Sigler's "Half a Man," and Ja Rule's "I Cry," which also happens to feature Lil' Mo. It was digitally released as an individual buzz single in June 17, 2008, and saw a limited international release as a B-side to the accompanying 12" single, "5 Boroughs," in June 24, 2008; alongside a US release in July 8, 2008.

Chart performance

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Cry (Lynn Anderson album)

Cry is a studio album by country music legend Lynn Anderson, released in 1972.

This album was based on Lynn Anderson's hit from early 1972, "Cry", which hit No. 3 on the Billboard Country charts, and No. 1 on the Cashbox Country charts. In addition the song also reached No. 71 on the Pop charts, and No. 16 on the Adult Contemporary charts that year. This album shows Anderson's new direction into placing her voice into more Pop-oriented songs, including "Cry" (originally a No. 1 Pop hit for Johnnie Ray in 1951). After having a No. 1 Country and Pop hit in late 1970, "(I Never Promised You a) Rose Garden", her record company set her records out more for the Pop market, and never looked back. This helped Lynn Anderson gain the biggest success she ever had for a number of years. Thus, this left Anderson from recording the hard Country material she recorded for her late 60s albums under Chart Records.

Husband, Glenn Sutton helped produce this album with producing legend, Clive Davis. Most of the songs featured here are Pop songs, like the Addrisi Brothers' "We've Got to Get It on Again" and Sonny & Cher's "When You Say Love". With the help of legendary Country producer, Billy Sherrill, Sutton wrote some of the songs for this album, some of which had been previously hits for Country singers, like Barbara Mandrell's "Tonight My Baby's Coming Home". This album was big-selling album, reaching No. 2 on the "Top Country Albums" chart and No. 114 on the "Billboard 200" albums chart.

Pickaxe

A pickaxe or pick is a hand tool with a hard head attached perpendicular to the handle.

Some people make the distinction that a pickaxe has a head with a pointed end and a blunt end, and a pick has both ends pointed, or only one end; but the international Oxford Dictionary of English states that both words mean the same, i.e. a tool with a long handle at right angles to a curved iron or steel bar with a point at one end and a chisel or point at the other, used for breaking up hard ground or rock.

The head is usually made of metal, and the handle is most commonly wood, metal or fiberglass. The head is a spike ending in a sharp point, may curve slightly, and often has a counter-weight to improve ease of use. The stronger the spike, the more effectively the tool can pierce the surface. Rocking the embedded spike about and removing it can then break up the surface.

The counterweight nowadays is nearly always a second spike, often with a flat end for prying.

The pointed edge is most often used to break up rocky surfaces or other hard surfaces such as concrete or hardened dried earth. The large momentum of a heavy pickaxe on a small contact area makes it very effective for this purpose. The chiseled end, if present, is used for purposes including cutting through roots.

List of five-number lottery games

The following is a list of lottery games in the United States and Canada in which five regular numbers are drawn from a larger set of numbers. The list includes the name, the number field for each, and the frequency of drawings. All pick-5 games in the U.S. and Canada are drawn multiple times per week (usually nightly, including Sundays and holidays); some lotteries now draw a five-number game twice daily.

Most U.S. pick-5 games now have a progressive jackpot, even in games that are drawn daily; in unusual cases, a single ticket has won a cash prize in excess of $1 million. A common top prize in non-jackpot pick-5 games is $100,000. (In the lists below, games with a jackpot do not have a minimum jackpot listed.) Depending on the game, a minimum of either two or three numbers (not counting a "bonus ball") must be matched for a winning ticket. (A 2/5 match usually results in a free play for that game, or a "break-even" win; for the latter, the player wins back their stake on that particular five-number wager.) Prize payouts depending on the game are either fixed (with parimutuel exceptions), are always parimutuel, or feature a parimutuel jackpot with fixed lower-tier prizes.

PICK1

PRKCA-binding protein is a protein that in humans is encoded by the PICK1 gene.

Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Interactions

PICK1 has been shown to interact with: