- published: 17 Sep 2021
- views: 575870
FGL may refer to:
Fibrinogen-like protein 2, also known as FGL2, is a protein which in humans is encoded by the FGL2 gene.
FGL2 is a 439 amino acid secreted protein that is similar to the β- and γ-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds.
This protein may play a role in physiologic functions at mucosal sites.
FGL2 is a protein that exhibits pleiotropic effects within the body and is an important immune regulator of both innate and adaptive responses. The protein exists as both a Type II transmembrane protein (with the carboxy terminus on the extracellular side of the plasma membrane) found on the surface of macrophages and endothelial cells and can be constitutively secreted by both CD4+ and CD8+ T cells.
Membrane bound FGL2 (mFGL2) exhibits a prothrombinase activity, resulting in fibrin deposition, vascular thrombosis and tissue inflammation within an affected tissue, largely contributing to the innate arm of immunity. Through mFGL2’s actions of promoting vascular thrombosis and tissue inflammation, it has been implicated in the pathogenesis of viral-induced fulminant hepatitis in acute hepatitis B infections. Hepatocellular necrosis ensues rapidly, due to the HBV nucleocapsid protein’s ability to markedly upregulate expression of the mFGL2 prothrombinase, leading to fibrin deposition within the vasculature networks that supply blood to the liver.
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene. Four splice variants exist for this gene.
Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation.
FGL-1 may play a role in the development of hepatocellular carcinomas.
Music video by Florida Georgia Line performing Always Gonna Love You. © 2021 Big Machine Label Group, LLC http://vevo.ly/8E2oYt
Music video by Florida Georgia Line performing This Is How We Roll. (C) 2014 Universal Republic Nashville Records #FloridaGeorgiaLine #ThisIsHowWeRoll #vevo #country #vevoofficial #OfficialMusicVideo
Music video by Florida Georgia Line performing Simple. © 2018 Big Machine Label Group, LLC http://vevo.ly/vRWsrb
Official video for "Lil Bit" by Nelly & Florida Georgia Line. Listen & Download "Lil Bit" out now: https://nelly.lnk.to/LilBit Amazon Music - https://nelly.lnk.to/LilBit/AmazonMusic Apple Music - https://nelly.lnk.to/LilBit/AppleMusic iTunes - https://nelly.lnk.to/LilBit/iTunes Spotify - https://nelly.lnk.to/LilBit/Spotify YouTube Music - https://nelly.lnk.to/LilBit/YouTubeMusic Follow Nelly Facebook - https://www.facebook.com/nelly Instagram - https://www.instagram.com/nelly/ Twitter - https://twitter.com/Nelly_Mo Follow Florida Georgia Line Facebook - https://www.facebook.com/floridageorgialine Instagram - https://www.instagram.com/floridageorgialine Twitter - https://twitter.com/FLAGALine #Nelly #FloridaGeorgiaLine #LilBit
Music video by Florida Georgia Line performing Round Here. ©: Republic Nashville, a division of UMG Recordings, Inc. #FloridaGeorgiaLine #RoundHere #vevo #country #vevoofficial #OfficialMusicVideo
“H.O.L.Y.” is on FGL’s latest release DIG YOUR ROOTS. Click here: http://smarturl.it/DigYourRoots Music video by Florida Georgia Line performing H.O.L.Y.. (C) 2016 Big Machine Label Group, LLC http://vevo.ly/IAnkaR #FloridaGeorgiaLine #HOLY #vevo #country #vevoofficial #OfficialMusicVideo
“May We All” is on FGL’s latest release DIG YOUR ROOTS. Click here: http://smarturl.it/DigYourRoots Music video by Florida Georgia Line performing May We All. (C) 2016 Big Machine Label Group, LLC http://vevo.ly/nVtOJU #FloridaGeorgiaLine #MayWeAll #vevo #country #vevoofficial #OfficialMusicVideo
Sun Daze can be found on FGL’s latest release ANYTHING GOES. Click here to purchase: http://smarturl.it/FGLAnythingGoes Music video by Florida Georgia Line performing Sun Daze. (C) 2014 Republic Records, a Division of UMG Recordings Republic Records (Republic Nashville) #FloridaGeorgiaLine #SunDaze #vevo #country #vevoofficial #OfficialMusicVideo
“Dirt" can be found on FGL’s latest release ANYTHING GOES. Click here to purchase: http://smarturl.it/FGLAnythingGoes Florida Georgia Line - Dirt Buy Now! http://smarturl.it/FGLdirt #FloridaGeorgiaLine #Dirt #vevo #country #vevoofficial #OfficialMusicVideo
Music video by Florida Georgia Line performing Cruise. (C) 2012 Universal Republic Nashville Records #FloridaGeorgiaLine #Cruise #vevo #country #vevoofficial #OfficialVideo
FGL may refer to:
[Verse 1]
I'm the eye of a violent storm, darkest cloud on a funnel mission
With slugs that travel through barrels with tunnel vision (WHOA!)
Clips to extensive spit to offensive
From the chi love don't live here any more rent to expensive
Push weight in a sentence 'til I'm knocked awaiting my sentence
Am I god's personal weapon of mass destruction or Satan's apprentice?
Nice but I'm hating repentance
Coca cola killer twist your shit leave a prize under every cap
No blatant ???
Look let the drama come, I'm bent on havoc
The crown don't move whoever intends on grabbing it
Is fighting of full blown aids with Flintstone tablets
Whether niggaz feel me or not regardless style heartless foul
Spit in front of the hardest crowds
If they start booing I'm sticking fans Artest style
Recognize bitch the darkest cloud
Motherfuckers I'm back!
[Chorus: x2]
Guess whose back in this bitch again full turn
Yep your worst fears confirmed
You betta learn
The crown don't move, wait your turn
What else can I siiizzzay
V to the iiiizzzaaa!! (Scratched Jigga)
[Verse 2]
Long range shitting
I'm an asshole with a built in sniper lense
Your top ten rappers top ten got no type of wins
I've been nasty since birth
Fuck a jersey the hall of fame retired a couple of my shitty dippers then
The truth since my umbilical was chopped from my navel
Darkest cloud didn't go pop but I'm stable
Never been dropped from a label
I gage my career to a fat bitch at a buffet and brought a lot to the table
The games lets die verse so fuck peace until I left my curse
And rookies claiming they the best since big death died worst
Bitch please you've yet to spit shit that could fuck with a left eye verse
(That's Real Talk)
I'm sonning as long as the one in the sky hung
They say the good die young
Mostly over bullshit and women that's high strung
But them same bitch's is throwing me pussy like they running up's for the siyun
Huh!
[Chorus]
[Verse 3]
I hold it down for my niggaz that's spending there last days in the county
And for the bitch's that's sending them work laced in them brownies
For them niggaz that's popped Jess I'm raising the bounty
'Til your brains on your moms with the shell casings around me
That's real talk with the real chalk on ya, resting in a twin glock coma
The flows glaucoma who's seeing me now? Out MCing me now?
I win at 106 shitting on the audience with AJ and free in the crowd
I ain't no fucking mixed tape fake thug take an ak slug in that pussy shit fake mug!
It's alright to show the late greats love
But some of y'all are riding dicks and don't know it like a date-rape drug
Catch me with your little niece on the couch
Kick her out the house with no blouse, Capris on slouch
I ain't fuck I just poked at her throat like a Capri sun pouch
Point blank I'm a fucking problem capech I'm out
And there it is....
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