- published: 17 Jan 2016
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Flavivirus is a genus of viruses in the family Flaviviridae. This genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis.
Flaviviruses are named from the yellow fever virus, the type virus for the family; the word flavus means "yellow" in Latin. The name yellow fever originated from its propensity to cause yellow jaundice in victims.
Flaviviruses share several common aspects: common size (40–65 nm), symmetry (enveloped, icosahedral nucleocapsid), nucleic acid (positive-sense, single-stranded RNA around 10,000–11,000 bases), and appearance in the electron microscope.
Most of these viruses are transmitted by the bite from an infected arthropod (mosquito or tick) and hence, classified as arboviruses. Human infections with these viruses are typically incidental, as humans are usually unable to replicate the virus to high enough titers to reinfect the arthropods needed to continue the virus lifecycle – man is then a dead end host. The exceptions to this are the yellow fever, dengue, and zika viruses, which still require mosquito vectors, but are well-enough adapted to humans as to not necessarily depend upon animal hosts (although they continue to have important animal transmission routes, as well).
Artistic rendering of dengue virus as it undergoes the key cell entry step of membrane fusion. The virus fuses its lipid membrane with the membrane of an endosomal vesicle inside the host cell. At least two dengue virus envelope protein trimers are required for fusion. Completion of membrane fusion requires the helical stem region to anneal onto the core of the E trimers. Zika virus and other flaviviruses are expected to have the same fusion mechanism. Animation created by Yorgo Modis, Digizyme, Inc. and XVIVO Scientific Animation with funding from the US National Institutes of Health.
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Table of Contents: 01:28 - Clicker Question 16 04:14 - Clicker Question 17 06:26 - Big Picture - Flaviviruses 07:21 - Key concepts 07:56 - Flaviviruses 09:02 - Flaviviruses 09:57 - Flaviviral diseases 11:12 - Yellow Fever 15:38 - VF-Vax 20:22 - Yellow Fever 2010 23:13 - Dengue (Haemorragic) Fever 25:48 - Spread of Dengue Virus 25:49 - Dengue (Haemorragic) Fever 26:25 - Spread of Dengue Virus 26:52 - Dengue - 108/year 27:17 - http://www.cdc.gov/dengue/ 28:44 - Vaccines 30:33 - West Nile 31:37 - West Nile Dec 2012 33:07 - http://diseasemaps.usgs.gov/ 33:21 - Hepatitis C 36:01 - Gilead Biosciences 36:42 - The competition - Olysio 36:58 - Costs 38:54 - The competition - Olysio 38:55 - Hepatitis C 39:01 - Gilead Biosciences 39:03 - The competition - Olysio 39:09 - Costs 41:37 - Structure - Fla...
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flavi2-- Created using PowToon -- Free sign up at http://www.powtoon.com/youtube/ -- Create animated videos and animated presentations for free. PowToon is a free tool that allows you to develop cool animated clips and animated presentations for your website, office meeting, sales pitch, nonprofit fundraiser, product launch, video resume, or anything else you could use an animated explainer video. PowToon's animation templates help you create animated presentations and animated explainer videos from scratch. Anyone can produce awesome animations quickly with PowToon, without the cost or hassle other professional animation services require.
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Dengue fever and West Nile fever are mosquito-borne diseases that affect hundreds of millions of people worldwide each year, but there is no vaccine against either of the related viruses. A team of scientists at University of Michigan, along with colleagues at Purdue University, discovered a key aspect to both how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread. Researchers led by Janet Smith of U-M's Life Sciences Institute describe for the first time the structure of NS1, a protein that helps the flavivirus family replicate and spread infection. NS1 is produced inside infected cells, where it plays a key role in replication of the virus. NS1 is also released into the bloodstream, where it may help disguise the infection from the ...
The antigenic 15 apr 2017 flavivirus associated hemorrhagic fevers the vectors for chikungunya virus are two mosquito species aedes aegypti and albopictus zika is a member of family, small, enveloped these same mosquitoes that spread dengue viruses 8 jun this page includes following topics synonyms flavivirus, flaviviridae diagnostics zika, & medlabmagazine zikv family flaviviruses was first 1 feb both fever (dfv) (zikv) whereas (chikv) belongs to alphavirus familiae [1]. Revised diagnostic testing for zika, chi. Googleusercontent search. The natural zoonotic cycles that maintain the virus do not usually involve humans. The growing global threat of zika, dengue and chikungunya viruses. Google a ncsu howdoeschikungunyacomparetodengue similar 6 aug 2014 'we now face new threat posed by the u...
"Aedes aegypti e Aedes Albopictus - Uma Ameaça nos Tropicos" Tem como objetivo contribuir para um melhor entendimento da dispersão de ambas as espécies pelos continentes e de seu papel como transmissores de viroses, tendo como enfoque principal a dengue, que nos últimos anos vem provocando várias epidemias em diversos países de clima tropical. O Documentário é Composto de Imagens reais e virtuais dos Mosquitos, mostrando os continentes de origem , a sua dispersão pelo mundo, as suas características morfológicas, os seus habitos alimentares, os seus mecanismos de alimentação , a sua reprodução e o ambiente onde vivem. Documentário Produzido pelo Serviço de Produção e Tratamento de Imagem do Instituto Oswaldo Cruz / Fiocruz. Direção: Genilton José Vieira. Produção Genilton José Vieira e Le...
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