Cyclist critically hurt as five riders 'struck' by car in West End

A cyclist has been critically injured and another four are being treated in hospital after a car "struck" a group of riders in inner-city Brisbane.

Paramedics arrived to find riders lying on the ground and others seemingly concussed after the crash, about 6.20am on a West End street popular with cyclists.

Cyclist David Shelberg said he and a group of about a dozen friends were riding down Dornoch Terrace when a car tried to U-turn.

Mr Shelberg was in front of the accident and escaped unharmed but other friends taking part in their regular Friday morning ride were injured.

"I don't know how they really are. My wife was the last one to go to hospital," he said.

"She wasn't too bad. She's just left now.

"The car looks like it's been hit by another car, doesn't it?"

A Queensland Ambulance Service spokeswoman said one woman was taken to hospital with critical injuries but in a stable condition while the other four patients were stable.

Dornoch Terrace was briefly closed as emergency services responded to the accident but reopened before 7.30am.

Dozens more cyclists continued down the road throughout the morning.

Queensland Ambulance Service acting operations supervisor Matthew Davis said the scene his officers arrived to was "quite confronting".

"It's speculation at best on our part but we've sort of been advised that potentially the angle of the sun may have come into play," he said.

"What we do know is that the car was essentially turning out onto the road and didn't have visibility of the cyclists so we're assuming that's what's resulted in the accident."

Friends who were helping a man take his belongings out of the car involved declined to comment.

Paramedics assessed the driver but he did not have any obvious injuries and did not want to be taken to hospital.

Mr Davis said five patients had been "struck" by the vehicle.

The most seriously injured was a woman, believed to be in her mid-40s, who was rushed to the Princess Alexandra Hospital.

Another badly injured patient had a broken leg and chest injuries, while the other three were being treated for less serious injuries, Mr Davis said.

"Obviously we have high concerns for any cyclists that's been struck by a car."

Resident Colin Veerman and his wife heard the crash from their home and rushed outside to see cyclists on the ground.

"One lady wasn't too bad but the rest were in a bad way," he said.

Mr Veerman said the road was very popular with cyclists.

"Especially Friday mornings, Saturday mornings, hundreds of them travel down here at incredible speed," he said.

"It's just an accident waiting to happen."