U.S. Route 441 is a spur route of U.S. Route 41. It currently runs for 939 miles (1,511 km) from U.S. Route 41 in Miami, Florida to U.S. Route 25W in Lake City, Tennessee. Between its termini, US 441 passes through the states of Florida, Georgia, North Carolina, and Tennessee. The route acts as a connector between numerous major urban areas, including Miami, Orlando, Ocala, Gainesville, Athens and Knoxville. It also crosses the Great Smoky Mountains National Park, where it meets the southwestern end of the Blue Ridge Parkway, and where no trucks or other commercial traffic are allowed.

US 441 begins northbound at Southwest 7th Street, which is westbound U.S. Route 41, and ends southbound on Southwest 8th Street, which is eastbound U.S. Route 41 in downtown Miami (both are one way streets). The route parallels Interstate 95 north out of Miami to western Aventura, where I-95 heads northeast to access Fort Lauderdale and the remainder of the eastern Florida coast. However, the route is soon joined by the tolled Florida's Turnpike, which follows US 441 north to West Palm Beach. In between, the route interchanges with the Turnpike at exit 62 via State Road 870 (Commercial Blvd.) in Tamarac. Additionally, US 441 meets Interstate 595(Exits 8 and 8B) west of Fort Lauderdale and the tolled State Road 869 in Coconut Creek.

The Orange blossom is the fragrant flower of the Citrus sinensis (orange tree). It is used in perfume making, has been written about as an aphrodisiac, is the state flower of Florida. It is traditionally associated with good fortune and has been popular in bridal bouquets and head wreaths for weddings. Orange blossom essence is an important component in the making of perfume. The petals of orange blossom can also be made into a delicately citrus-scented version of rosewater; orange blossom water (aka orange flower water), a common part of both French cuisine and Middle Eastern cuisine (most often as an ingredient in desserts and baked goods).

In the United States, orange flower water is used to make orange blossom scones and marshmallows.

Orange blossom honey (citrus honey) is produced by putting beehives in the citrus groves during blooming period. This also pollinates seeded citrus varieties. Orange blossom honey is highly prized and tastes much like the fruit.

The orange blossom gives its touristic nickname to the Costa del Azahar ("Orange-blossom coast"), the Castellon seaboard.