Gregory House, M.D., (often simply referred to as House) is the title character and an antihero of the American television series House, played by Hugh Laurie. House is the Chief of Diagnostic Medicine at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey, where he leads a team of diagnosticians. House's character has been described as a misanthrope, cynic, narcissist and curmudgeon. He is the only character to appear in all 177 episodes. The season 6 premiere is the only episode in which House is the only regular character to appear, besides Wilson (briefly).

In the series, the character's unorthodox diagnostic approaches, radical therapeutic motives, and stalwart rationality have resulted in much conflict between him and his colleagues. House is also often portrayed as lacking sympathy for his patients and having a practice allowing him the time to solve pathological enigmas. The character is partly inspired by Sherlock Holmes. A portion of the show's plot centers on House's habitual use of Vicodin to manage pain stemming from a leg infarction involving his quadriceps muscle some years earlier, an injury that forces him to walk with a cane. This addiction is also one of the many parallels to Holmes, who was a habitual user of cocaine and opium.

James Hugh Calum Laurie, OBE (born 11 June 1959), known as Hugh Laurie (/ˈhjuː ˈlɒri/), is an English actor, voice artist, comedian, writer, musician, recording artist, and director. He first became known as one half of the Fry and Laurie double act, along with his friend and comedy partner Stephen Fry, whom he joined in the cast of Blackadder and Jeeves and Wooster from 1987 to 1999.

From 2004 to 2012, he played Dr Gregory House, the protagonist of House, for which he received two Golden Globe awards, two Screen Actors Guild awards, and six Emmy nominations. As of August 2010, Laurie is the highest paid actor in a drama series on US television. He has been listed in the 2011 Guinness Book of World Records as the highest paid actor ever in a TV Drama—earning US$ 700,000 per episode in House—and for being the most watched leading man on television.

Laurie was born in Oxford, Oxfordshire, England. The youngest of four children, Laurie has an older brother named Charles and two older sisters named Susan and Janet. He had a somewhat strained relationship with his mother, Patricia (née Laidlaw). His father, Ran Laurie, was a medical doctor who also won an Olympic gold medal in the coxless pairs (rowing) at the 1948 London Games.