Why Does Testosterone Decrease | The Truth About How to Boost Testosterone- Thomas DeLauer

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• published: 06 Oct 2016
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A Big Reason some of the top executives I work with feel low, is because of testosterone. http://www.ThomasDeLauer.com Why Does Testosterone Decrease ? How Testosterone Declines in Men (Physiologically, HPTA Axis, etc) HPTA = Hypothalamic Pituitary Gonadal Axis This axis produces circulating steroids important for male sexual function, fertility and development. Prostate and penis are steroid sensitive organs impacted by the regulation of the HPTA This reproductive axis consists of three parts: 1. Hypothalamus -Produces GnRH (gonadotropin-releasing hormone) 2. Pituitary Gland -GnRH is sent to the pituitary gland where it stimulates the synthesis and release of gonadotropic hormones LH and FSH. 3. Testis -Gonads carry LH to the testis where they stimulate testosterone production through the testicular Leydig cells -Testosterone is produced by conversion of cholesterol -FSH is crucial for spermatogenesis Dihydrotestosterone (DHT) is the activated form of testosterone 2% of testosterone is free or unbound, with the remainder being bound to SHBG (sex hormone-binding globulin), albumin- and cortisol-binding globulin. Bioavailable testosterone is the testosterone that is not bound to SHBG Testosterone and DHT act on organs. -Causes development of secondary sexual characteristics -Inhibit secretion of LH and FSH by the pituitary gland, thus stops further testosterone production = negative feedback loop. -There exist androgen receptors in the pituitary and the hypothalamic neurons that bind to testosterone and signal to stop GnRH release Homeostasis is maintained through this loop - once testosterone stops being produced, this inhibited secretion stops and GnRH again causes LH and FSH release to produce further testosterone. As men age, they undergo hormonal level changes: -Testosterone decrease -LH and FSH increase -Other hormones that decrease: T3, insulin, growth hormone/insulin-like growth factor 1, thyroid stimulating hormone -Also an increase in SHBG -Dihydrotestosterone levels are unchanged -Estrogen levels unchanged As men age, the decrease in testosterone paired with the increase in SHBG leads to a decline in free, or bioavailable, testosterone These hormonal changes start in the 30s and are well established by the 50s. Levels of testosterone vary greatly between men and not all men will be classified as hypogonadal as they age What causes these hormone changes? 1. Testicular failure due to a decline in Leydig cell mass 2. Hypothalamic-pituitary system, or secondary hypogonadism failure -Believed not to be due to primary hypogonadism (disease of the testes) due to small increase in LH and decrease in responsiveness of LH and FSH to GnRH 3. Change in androgen receptor site sensitivity Can distinguish between those with pituitary disorders or hypothalamic disease by administering GnRH. Those with pituitary disorders will not respond by producing more LH and FSH whereas those with hypothalamic disorders will respond with increased LH and FSH Numerous studies have shown a positive impact of healthy, dietary fat intake on testosterone levels in men. Cholesterol is tied to the production of sex hormones. Testosterone is created in the Leydig cells when LH triggers the cells to convert cholesterol into testosterone. Cholesterol is the precursor to pregnenolone, which is the precursor of steroid hormones. Pregnenolone is the precursor of progesterone, which is then converted into testosterone (progesterone is also converted into cortisol and aldosterone). Consuming greater amounts of healthy fats can boost HDL cholesterol and thus provide more fuel for the production of testosterone. You want your diet to contain a minimum of 20% fat in order to have sufficient cholesterol. Consume: fatty fish, olive oil, nuts and avocados. References: 1. Age-associated testosterone decline in men: clinical issues for psychiatry http://ajp.psychiatryonline.org/doi/full/10.1176/ajp.155.10.1310 2. Pathophysiology course - endocrine module - male gonadal disorders https://www.uthsc.edu/endocrinology/documents/ch08-syllabus-Childress.pdf 3. Cholesterol is the precursor for all steroid hormones http://www.cholesterol-and-health.com/Steroid-Hormones.html 4. Testosterone physiology in resistance exercise and training https://www.ncbi.nlm.nih.gov/pubmed/21058750 5. Diet and serum sex levels in healthy men https://www.ncbi.nlm.nih.gov/pubmed/6538617 http://www.sciencedirect.com/science/article/pii/0022473184902541 * 6. An Introduction to Steroids and Negative Feedback Loops www.jordanhs.portal.rschooltoday.com/page/4498/117/notes/320/1757 7. Testosterone Treatment for Men - T, HCG, ARIMIDEX https://www.menshormonalhealth.com/testosterone-therapy.html 8. The Interaction of Testosterone and Cortisol is Associated with Attained Status in Male Executives http://scholar.harvard.edu/files/jenniferlerner/files/sherman_lerner_testosterone_cortisol.pdf