Desperate Housewives is an American comedy-drama series that aired on ABC (American Broadcasting Company). It focuses on the residents living on the fictional Wisteria Lane as narrated by their deceased neighbor, Mary Alice Young (Brenda Strong). Specifically, the series follows four protagonists and Mary Alice's friends, Susan Mayer (Teri Hatcher), Lynette Scavo (Felicity Huffman), Bree Van de Kamp (Marcia Cross), and Gabrielle Solis (Eva Longoria). Desperate Housewives features an ensemble cast, which also includes the women's husbands, children, love interests, neighbors, and other acquaintances.
The following are characters whose portrayer received "Starring" billing at any point of the series. They are sorted in the order in which they were introduced to the main cast, and not by episode count, screen time or popularity.