PAX6

Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a protein that in humans is encoded by the PAX6 gene. Pax6 is a transcription factor present during embryonic development. The encoded protein contains two different binding sites that are known to bind DNA and function as regulators of gene transcription. It is a key regulatory gene of eye and brain development. Within the brain, the protein is involved in development of the specialized cells that process smell. As a transcription factor, Pax6 activates and/or deactivates gene expression patterns to ensure for proper development of the tissue. Mutations of the Pax6 gene are known to cause various disorders of the eyes. Two common disorders associated with a mutation are: aniridia, the absence of the iris, and Peter’s anomaly, thinning and clouding of the cornea. Scientists have created a “tae” model using mice during which time the mouse does not express Pax6. The "knockout” model is eyeless or has very underdeveloped eyes further indicating Pax6 is required for proper eye development.

The Horizon (web series)

The Horizon is a web series which premiered on YouTube. It is the most watched online series made out of Australia and the most watched gay web series in the world.

The Horizon was created by Adam Jones and Boaz Stark. Season 1 was written in 2009 by Boaz Stark (a scriptwriter for 25 years, former writer of Sons and Daughters, Neighbours, Always Greener and Packed to the Rafters). Season 1 was produced by Mark Benko Ure and Christian Taylor and directed by Boaz Stark and Mark Benko Ure. Seasons 2, 3 and 4 were written and directed by Boaz Stark and produced by Brian Cobb and his company Cobbstar Productions. Brian had two short films chosen and screened at the 2012 and 2013 Cannes film festival.

The Horizon is made in partnership with the Aids Council of New South Wales (ACON). The budget for the 1st series was $3,000 (Australian dollars) but went viral. Now with 3 seasons available for view at thehorizon.tv, the series has significantly higher production values and stands at over 22,000,000 views, growing by 40,000 - 60,000 views daily (July 2014). It is the most successful online series made in Australia and the most watched gay web series in the world.

Bring Me the Horizon

Bring Me the Horizon are a British rock band from Sheffield, Yorkshire. Formed in 2003, the group currently consists of lead vocalist Oliver Sykes, lead guitarist Lee Malia, bassist Matt Kean, drummer Matt Nicholls and keyboardist Jordan Fish. They are signed to RCA Records globally and Columbia Records exclusively in the US. The style of their early work, including their debut album Count Your Blessings, has primarily been described as deathcore, but they started to adopt a more eclectic style of metalcore on subsequent albums. Furthermore, their latest album That's the Spirit, marked a shift in their sound to less aggressive rock music styles.

Bring Me the Horizon released their debut album Count Your Blessings in 2006. Upon release, the album was met with great polarisation amongst the public and critical disdain. The band began to break away from their controversial sound with Suicide Season (2008), which proved to be a creative, critical and commercial turning point for the band. Bring Me the Horizon then released their third album There Is a Hell, Believe Me I've Seen It. There Is a Heaven, Let's Keep It a Secret. In 2010, propelling them to greater international fame, whilst incorporating influences from classical, electronica and pop. Their major label debut, Sempiternal achieved Gold certification in Australia (35,000) and Silver in the United Kingdom (60,000). That's the Spirit debuted at #2 in the UK charts, selling almost 2 times the previous album with 44,300 first week sales. Aside from these five albums, they have also released two extended plays and a live album.

Slipknot

Slipknot may refer to:

See also