- published: 23 Mar 2010
- views: 40652
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http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
- published: 10 Oct 2012
- views: 7433
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
- published: 02 Nov 2012
- views: 2447
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
- published: 23 Mar 2010
- views: 16571
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
- published: 16 Nov 2013
- views: 264
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
- published: 18 Dec 2012
- views: 4497
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobel Media AB
source: http://Nobelprize.org
- published: 11 Dec 2012
- views: 3085
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
- published: 19 Mar 2013
- views: 711
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford.
www.gopowerforward.com
www.gopowerforward.com/blog
- published: 17 May 2017
- views: 18
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
- published: 16 Nov 2013
- views: 4590
Robert Lefkowitz
Robert Joseph Lefkowitz (born April 15, 1943) is an American physician (internalist and cardiologist) and biochemist. He is best known for his groundbreaking discoveries that reveal the inner workings of an important family G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.
Early life
Lefkowitz was born on April 15, 1943, in The Bronx, New York to Jewish parents Max and Rose Lefkowitz. Their families had immigrated to the United States from Poland in the late 19th century.
After graduating from the Bronx High School of Science in 1959, he attended Columbia College from which he received a Bachelor of Arts in chemistry 1962.
He graduated from Columbia University College of Physicians and Surgeons in 1966 with an M.D. Degree. After serving an internship and one year of general medical residency at the College of Physicians and Surgeons, he served as Clinical and Research Associate at the National Institutes of Health from 1968 to 1970.
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This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
Nobel Prize
The Nobel Prize (Swedish pronunciation: [nʊˈbɛl], Swedish definite form, singular: Nobelpriset; Norwegian: Nobelprisen) is a set of annual international awards bestowed in a number of categories by Swedish and Norwegian committees in recognition of academic, cultural and/or scientific advances.
The will of the Swedish inventor Alfred Nobel established the prizes in 1895. The prizes in Chemistry, Literature, Peace, Physics, and Physiology or Medicine were first awarded in 1901. The related Nobel Memorial Prize in Economic Sciences was established by Sweden's central bank in 1968. Medals made before 1980 were struck in 23 carat gold, and later from 18 carat green gold plated with a 24 carat gold coating. Between 1901 and 2015, the Nobel Prizes and the Prize in Economic Sciences were awarded 573 times to 900 people and organizations. With some receiving the Nobel Prize more than once, this makes a total of 870 individuals (822 men and 48 women) and 23 organizations.
The prize ceremonies take place annually in Stockholm, Sweden, except for the peace prize which is held in Oslo, Norway and each recipient, or laureate, receives a gold medal, a diploma and a sum of money that has been decided by the Nobel Foundation. (As of 2012, each prize was worth SEK8 million or about US$1.2 million, €0.93 million or £0.6 million.) The Nobel Prize is widely regarded as the most prestigious award available in the fields of literature, medicine, physics, chemistry, peace, and economics.
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This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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Duke University
Duke University is a private research university located in Durham, North Carolina, United States. Founded by Methodists and Quakers in the present-day town of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James Buchanan Duke established the Duke Endowment, at which time the institution changed its name to honor his deceased father, Washington Duke.
The university's campus spans over 8,600 acres (35 km2) on three contiguous campuses in Durham as well as a marine lab in Beaufort. Duke's main campus—designed largely by architect Julian Abele—incorporates Gothic architecture with the 210-foot (64 m) Duke Chapel at the campus' center and highest point of elevation. The first-year-populated East Campus contains Georgian-style architecture, while the main Gothic-style West Campus 1.5 miles away is adjacent to the Medical Center. Duke is also the 7th wealthiest private university in America with $11.4 billion in cash and investments in fiscal year 2014.
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This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
Doctor Robert
"Doctor Robert" is a song by the Beatles released on the album Revolver in the United Kingdom and on Yesterday and Today in the United States. The song was written by John Lennon and Paul McCartney and recorded in seven takes on 17 April 1966 with vocals overdubbed 19 April.
Musical characteristics
The song is written in the key of A major, though the key center is B, thereby making it in the Mixolydian mode. The musical arrangement has staggered layering, with backing vocals starting in the second verse, the lead guitar just before the bridge while the bridge itself has added harmonium and extra vocals mixed. John's lead is automatically double tracked with each of the two slightly-out-of-phase tracks split onto separate stereo channels; creating a surrealistic effect supporting the lyric about drug use. An interesting feature is the suitably "blissful" modulation (on "well, well well you're feeling fine") to the key of B on the bridge via an F#7 pivot chord (VI7 in the old key of A and V7 in the new key of B) The extended jam that lasts 43 seconds at the end was recorded, but it was removed and replaced with a fade-out. However, John says: "OK Herb", at the very last second of the song.
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This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
Robert
The name Robert is a Germanic given name, from Proto-Germanic *χrōþi- "fame" and *berχta- "bright". Compare Old Dutch Robrecht and Old High German Hrodebert (a compound of hruod "fame, glory" and berht "bright"). It is also in use as a surname.
After becoming widely used in Continental Europe it entered England in its Old French form Robert, where an Old English cognate form (Hrēodbēorht, Hrodberht, Hrēodbēorð, Hrœdbœrð, Hrœdberð) had existed before the Norman Conquest. The feminine version is Roberta. The Italian, Portuguese, and Spanish form is Roberto.
Similar to the name, Richard, "Robert" is also a common name in many Germanic languages, including English, German, Dutch, Norwegian, Swedish, Danish, and Icelandic. It can be used as a French, Hungarian, Finnish, and Estonian name as well.
Variations
Trivia
Robert, and also the name Joseph, were in the top 10 most given boys' names in the US for 47 years, from 1925 to 1972.
In Italy during the Second World War, the form of the name, Roberto, briefly acquired a new meaning derived from, and referring to the Rome-Berlin-Tokyo Axis.
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This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.
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55:15Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane ReceptorsRobert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org -
2:47Duke's Robert Lefkowitz shares in chemistry Nobel Prize
Duke's Robert Lefkowitz shares in chemistry Nobel PrizeDuke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s. They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease. The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times. The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue. "Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine." "We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows." In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center. Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990. They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony. -
59:57Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz on Science, Life and 'Eureka' MomentsDr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz. -
51:39Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
Robert Lefkowitz (Duke University) Part 2 Beta-arrestinsRobert Lefkowitz (Duke University) Part 2 Beta-arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org -
4:47Receptor Basics - Robert Lefkowitz (Duke University)
Receptor Basics - Robert Lefkowitz (Duke University)Receptor Basics - Robert Lefkowitz (Duke University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway. -
1:02:20Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala UniversityNobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012. For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates. http://www.uu.se -
1:16Robert Lefkowitz receives Nobel Prize
Robert Lefkowitz receives Nobel PrizeRobert Lefkowitz receives Nobel Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012 © Nobel Media AB source: http://Nobelprize.org -
58:03"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition. NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/ Help us caption & translate this video! http://amara.org/v/GAco/ -
1:58Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz: Failure is an ever-present companionDr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford. www.gopowerforward.com www.gopowerforward.com/blog -
4:50GPCR signaling - Robert Lefkowitz (Duke)
GPCR signaling - Robert Lefkowitz (Duke)GPCR signaling - Robert Lefkowitz (Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
Lefkowitz, Robert Filmography
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2012, role: actor , character name: Himself
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2012, role: actor , character name: Himself
Lefkowitz, Robert Filmography
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2001, role: actor , character name: Motel Manager
Lefkowitz, Robert Filmography
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2009, role: producer
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Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutiv...
published: 23 Mar 2010 -
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s. They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease. The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are calle...
published: 10 Oct 2012 -
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
published: 02 Nov 2012 -
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
published: 23 Mar 2010 -
Receptor Basics - Robert Lefkowitz (Duke University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
published: 16 Nov 2013 -
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012. For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates. http://www.uu.se
published: 18 Dec 2012 -
Robert Lefkowitz receives Nobel Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012 © Nobel Media AB source: http://Nobelprize.org
published: 11 Dec 2012 -
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science educa...
published: 19 Mar 2013 -
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford. www.gopowerforward.com www.gopowerforward.com/blog
published: 17 May 2017 -
GPCR signaling - Robert Lefkowitz (Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
published: 16 Nov 2013
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
- Order: Reorder
- Duration: 55:15
- Updated: 23 Mar 2010
- views: 40652
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of se...
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org
https://wn.com/Robert_Lefkowitz_(Duke_University)_Part_1_Seven_Transmembrane_Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org
- published: 23 Mar 2010
- views: 40652
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Order: Reorder
- Duration: 2:47
- Updated: 10 Oct 2012
- views: 7433
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University M...
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
https://wn.com/Duke's_Robert_Lefkowitz_Shares_In_Chemistry_Nobel_Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
- published: 10 Oct 2012
- views: 7433
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
- Order: Reorder
- Duration: 59:57
- Updated: 02 Nov 2012
- views: 2447
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke...
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
https://wn.com/Dr._Robert_Lefkowitz_On_Science,_Life_And_'Eureka'_Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
- published: 02 Nov 2012
- views: 2447
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
- Order: Reorder
- Duration: 51:39
- Updated: 23 Mar 2010
- views: 16571
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only d...
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
https://wn.com/Robert_Lefkowitz_(Duke_University)_Part_2_Beta_Arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
- published: 23 Mar 2010
- views: 16571
Receptor Basics - Robert Lefkowitz (Duke University)
- Order: Reorder
- Duration: 4:47
- Updated: 16 Nov 2013
- views: 264
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling path...
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
https://wn.com/Receptor_Basics_Robert_Lefkowitz_(Duke_University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
- published: 16 Nov 2013
- views: 264
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
- Order: Reorder
- Duration: 1:02:20
- Updated: 18 Dec 2012
- views: 4497
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 Decembe...
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
https://wn.com/Nobel_Laureate_In_Chemistry_Professor_Robert_J._Lefkowitz_Nobel_Lecture_At_Uppsala_University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
- published: 18 Dec 2012
- views: 4497
Robert Lefkowitz receives Nobel Prize
- Order: Reorder
- Duration: 1:16
- Updated: 11 Dec 2012
- views: 3085
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobe...
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobel Media AB
source: http://Nobelprize.org
https://wn.com/Robert_Lefkowitz_Receives_Nobel_Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobel Media AB
source: http://Nobelprize.org
- published: 11 Dec 2012
- views: 3085
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
- Order: Reorder
- Duration: 58:03
- Updated: 19 Mar 2013
- views: 711
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC Scho...
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
https://wn.com/The_Reluctant_Scientist_Keynote_Address_By_Dr._Robert_Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
- published: 19 Mar 2013
- views: 711
Dr. Robert Lefkowitz: Failure is an ever-present companion
- Order: Reorder
- Duration: 1:58
- Updated: 17 May 2017
- views: 18
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hugh...
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford.
www.gopowerforward.com
www.gopowerforward.com/blog
https://wn.com/Dr._Robert_Lefkowitz_Failure_Is_An_Ever_Present_Companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford.
www.gopowerforward.com
www.gopowerforward.com/blog
- published: 17 May 2017
- views: 18
GPCR signaling - Robert Lefkowitz (Duke)
- Order: Reorder
- Duration: 4:50
- Updated: 16 Nov 2013
- views: 4590
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
https://wn.com/Gpcr_Signaling_Robert_Lefkowitz_(Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
- published: 16 Nov 2013
- views: 4590
-
Robert J. Lefkowitz interview: Nobel Prize in Chemistry 2012
Telephone interview with Robert J. Lefkowitz following the announcement of the 2012 Nobel Prize in Chemistry, 10 October 2012. The interviewer is Adam Smith, Editorial Director of Nobel Media. More video and information at http://www.nobelprize.org
published: 11 Oct 2012 -
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 1 of 2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages. This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python." ibm.com/developerworks
published: 02 Aug 2011 -
Interview with Robert J. Lefkowitz, 2009 Frontiers of Knowledge Award in Biomedicine
Interview with Prof. Robert J. Lefkowitz, winner of the 2009 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category.
published: 28 Jun 2017 -
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 2 of 2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages. This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python." ibm.com/developerworks
published: 02 Aug 2011 -
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s. They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease. The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are calle...
published: 10 Oct 2012 -
Robert "r0ml" Lefkowitz interviewed at OSCON 2013
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked in IT organizations to facilitate access to information, and create highly resilient applications. His interests include semasiology and medieval history. He also juggles clubs.
published: 31 Jul 2013 -
David Mertz interviews Robert Lefkowitz for IBM's developerWorks, Part 2
David Mertz conducted a series of interviews with Robert Lefkowitz for IBM's developerWorks. These two videos were produced by David from that longer interview, with no additional editing by developerWorks.
published: 15 Feb 2013 -
Lefkowitz on fundamental, translational, and clinical research.
Duke University's President Richard H. Brodhead interviews Dr. Robert Lefkowitz, a 2012 Nobel Prize in chemistry winner and Howard Hughes Medical Institute investigator who has spent his 39-year research career at the Duke University Medical Center.
published: 09 Sep 2014 -
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science educa...
published: 19 Mar 2013 -
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
published: 30 Jul 2012
Robert J. Lefkowitz interview: Nobel Prize in Chemistry 2012
- Order: Reorder
- Duration: 6:20
- Updated: 11 Oct 2012
- views: 824
Telephone interview with Robert J. Lefkowitz following the announcement of the 2012 Nobel Prize in Chemistry, 10 October 2012. The interviewer is Adam Smith, Ed...
Telephone interview with Robert J. Lefkowitz following the announcement of the 2012 Nobel Prize in Chemistry, 10 October 2012. The interviewer is Adam Smith, Editorial Director of Nobel Media. More video and information at http://www.nobelprize.org
https://wn.com/Robert_J._Lefkowitz_Interview_Nobel_Prize_In_Chemistry_2012
Telephone interview with Robert J. Lefkowitz following the announcement of the 2012 Nobel Prize in Chemistry, 10 October 2012. The interviewer is Adam Smith, Editorial Director of Nobel Media. More video and information at http://www.nobelprize.org
- published: 11 Oct 2012
- views: 824
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 1 of 2
- Order: Reorder
- Duration: 8:06
- Updated: 02 Aug 2011
- views: 255
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates informa...
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages.
This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python."
ibm.com/developerworks
https://wn.com/David_Mertz_Interviews_From_Oscon_2011_Robert_Lefkowitz,_Part_1_Of_2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages.
This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python."
ibm.com/developerworks
- published: 02 Aug 2011
- views: 255
Interview with Robert J. Lefkowitz, 2009 Frontiers of Knowledge Award in Biomedicine
- Order: Reorder
- Duration: 5:20
- Updated: 28 Jun 2017
- views: 2
Interview with Prof. Robert J. Lefkowitz, winner of the 2009 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category.
Interview with Prof. Robert J. Lefkowitz, winner of the 2009 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category.
https://wn.com/Interview_With_Robert_J._Lefkowitz,_2009_Frontiers_Of_Knowledge_Award_In_Biomedicine
Interview with Prof. Robert J. Lefkowitz, winner of the 2009 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category.
- published: 28 Jun 2017
- views: 2
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 2 of 2
- Order: Reorder
- Duration: 9:27
- Updated: 02 Aug 2011
- views: 125
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates informa...
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages.
This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python."
ibm.com/developerworks
https://wn.com/David_Mertz_Interviews_From_Oscon_2011_Robert_Lefkowitz,_Part_2_Of_2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked primarily in large IT organizations where he facilitates information flows. His interests include semasiology and medieval history. In this two part interview, he and David speak about orality, literacy, rhetoric, internationalization and graphology, and the relationship of classical culture to programming languages.
This video is part of David Mertz coverage of OSCON 2011 for IBM developerWorks. David has been writing for developerWorks since 2000, including the columns Charming Python and XML Matters and a great many individual articles and tutorials. Check out his book "Text Processing in Python."
ibm.com/developerworks
- published: 02 Aug 2011
- views: 125
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Order: Reorder
- Duration: 2:47
- Updated: 10 Oct 2012
- views: 7433
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University M...
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
https://wn.com/Duke's_Robert_Lefkowitz_Shares_In_Chemistry_Nobel_Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
- published: 10 Oct 2012
- views: 7433
Robert "r0ml" Lefkowitz interviewed at OSCON 2013
- Order: Reorder
- Duration: 8:04
- Updated: 31 Jul 2013
- views: 272
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked in IT organizations to facilitate access to information, and cre...
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked in IT organizations to facilitate access to information, and create highly resilient applications. His interests include semasiology and medieval history. He also juggles clubs.
https://wn.com/Robert_R0Ml_Lefkowitz_Interviewed_At_Oscon_2013
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has worked in IT organizations to facilitate access to information, and create highly resilient applications. His interests include semasiology and medieval history. He also juggles clubs.
- published: 31 Jul 2013
- views: 272
David Mertz interviews Robert Lefkowitz for IBM's developerWorks, Part 2
- Order: Reorder
- Duration: 9:37
- Updated: 15 Feb 2013
- views: 24
David Mertz conducted a series of interviews with Robert Lefkowitz for IBM's developerWorks. These two videos were produced by David from that longer interview,...
David Mertz conducted a series of interviews with Robert Lefkowitz for IBM's developerWorks. These two videos were produced by David from that longer interview, with no additional editing by developerWorks.
https://wn.com/David_Mertz_Interviews_Robert_Lefkowitz_For_Ibm's_Developerworks,_Part_2
David Mertz conducted a series of interviews with Robert Lefkowitz for IBM's developerWorks. These two videos were produced by David from that longer interview, with no additional editing by developerWorks.
- published: 15 Feb 2013
- views: 24
Lefkowitz on fundamental, translational, and clinical research.
- Order: Reorder
- Duration: 1:03
- Updated: 09 Sep 2014
- views: 57
Duke University's President Richard H. Brodhead interviews Dr. Robert Lefkowitz, a 2012 Nobel Prize in chemistry winner and Howard Hughes Medical Institute inve...
Duke University's President Richard H. Brodhead interviews Dr. Robert Lefkowitz, a 2012 Nobel Prize in chemistry winner and Howard Hughes Medical Institute investigator who has spent his 39-year research career at the Duke University Medical Center.
https://wn.com/Lefkowitz_On_Fundamental,_Translational,_And_Clinical_Research.
Duke University's President Richard H. Brodhead interviews Dr. Robert Lefkowitz, a 2012 Nobel Prize in chemistry winner and Howard Hughes Medical Institute investigator who has spent his 39-year research career at the Duke University Medical Center.
- published: 09 Sep 2014
- views: 57
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
- Order: Reorder
- Duration: 58:03
- Updated: 19 Mar 2013
- views: 711
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC Scho...
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
https://wn.com/The_Reluctant_Scientist_Keynote_Address_By_Dr._Robert_Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
- published: 19 Mar 2013
- views: 711
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
- Order: Reorder
- Duration: 48:27
- Updated: 30 Jul 2012
- views: 3569
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known f...
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
https://wn.com/Jci's_Conversation_With_Giants_In_Medicine_Robert_Lefkowitz,_Joseph_Goldstein,_And_Michael_Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
- published: 30 Jul 2012
- views: 3569
-
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutiv...
published: 23 Mar 2010 -
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s. They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease. The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are calle...
published: 10 Oct 2012 -
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
published: 02 Nov 2012 -
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
published: 23 Mar 2010 -
Receptor Basics - Robert Lefkowitz (Duke University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
published: 16 Nov 2013 -
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012. For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates. http://www.uu.se
published: 18 Dec 2012 -
Robert Lefkowitz receives Nobel Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012 © Nobel Media AB source: http://Nobelprize.org
published: 11 Dec 2012 -
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science educa...
published: 19 Mar 2013 -
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford. www.gopowerforward.com www.gopowerforward.com/blog
published: 17 May 2017 -
GPCR signaling - Robert Lefkowitz (Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
published: 16 Nov 2013
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
- Order: Reorder
- Duration: 55:15
- Updated: 23 Mar 2010
- views: 40652
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of se...
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org
https://wn.com/Robert_Lefkowitz_(Duke_University)_Part_1_Seven_Transmembrane_Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the first segment of the lecture, the history of discovery in the field of seven transmembrane receptor research over the past forty years is reviewed. Highlights include overcoming initial skepticism that the receptors even existed; isolating the receptors as discrete biochemical entities and demonstrating their ligand binding and functional activating properties; discovering their seven transmembrane spanning arrangement and homology with the visual light receptor rhodopsin, thereby leading to the discovery of the wider seven transmembrane receptor superfamily; determination of the structure function relationships of the receptors by mutagenesis and chimeric receptor construction; discovery of constitutively active mutant receptors; discovery of the phosphorylation of the receptors by G protein coupled receptor kinases, and of the Beta-arrestins and of their universal mechanism for desensitizing the receptors. See more at www.ibiology.org
- published: 23 Mar 2010
- views: 40652
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Order: Reorder
- Duration: 2:47
- Updated: 10 Oct 2012
- views: 7433
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University M...
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
https://wn.com/Duke's_Robert_Lefkowitz_Shares_In_Chemistry_Nobel_Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center, is sharing the 2012 Nobel Prize in Chemistry with Brian K. Kobilka of Stanford University School of Medicine, who was a post-doctoral fellow in Lefkowitz's lab in the 1980s.
They are being recognized for their work on a class of cell surface receptors that have become the target of prescription drugs, including antihistamines, ulcer drugs and beta blockers to relieve hypertension, angina and coronary disease.
The receptors catch chemical signals from the outside and transmit their messages into the cell, providing the cell with information about changes occurring within the body. These particular receptors are called seven-transmembrane G protein-coupled receptors, or just "G-coupled receptors" for short. Serpentine in appearance, G-coupled receptors weave through the surface of the cell seven times.
The human genome contains code to make at least 1,000 different forms of these trans-membrane receptors, all of which are quite similar. The receptors also bear a strong resemblance to receptors that detect light in the eyes, smells in the nose and taste on the tongue.
"Bob's seminal discoveries related to G-protein coupled receptors ultimately became the basis for a great many medications that are in use today across many disease areas," said Victor J. Dzau, MD, Chancellor for Health Affairs and CEO, Duke University Health System. "He is an outstanding example of a physician-scientist whose impact can be seen in the lives of the countless patients who have benefited from his scientific discoveries. We are very proud of his magnificent achievements and grateful for his many contributions to Duke Medicine."
"We are thrilled that the Nobel Committee has recognized Bob's incredible body of work, and very proud that he has been on our faculty for his entire career," said Nancy Andrews, MD, PhD, Dean, Duke University School of Medicine. "Bob is not just an extraordinary scientist but also a remarkable mentor; he has had a profound influence on the careers of more than 200 students and postdoctoral fellows."
In addition to being one of the longest-serving Howard Hughes Medical Institute Investigators in history (36 years), Lefkowitz is famous on the Duke campus for the attention he gives to mentoring his students. His lab has produced more than 200 graduate students and post-docs, including R. Sanders "Sandy" Williams, who later became his dean at Duke, and several researchers who went on to become HHMI investigators themselves. Lefkowitz is a professor of biochemistry, immunology and medicine, and also a basic research cardiologist in the Duke Heart Center.
Among his students was Brian Kobilka, with whom he is sharing the Nobel Prize. Kobilka was a post-doctoral fellow in cardiology at Duke from 1984 to 1989 and part of Lefkowitz's lab. He joined the faculty of medicine and molecular and cellular physiology at Stanford in 1990.
They will receive the Nobel Prize in Stockholm at a Dec. 10 ceremony.
- published: 10 Oct 2012
- views: 7433
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
- Order: Reorder
- Duration: 59:57
- Updated: 02 Nov 2012
- views: 2447
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke...
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
https://wn.com/Dr._Robert_Lefkowitz_On_Science,_Life_And_'Eureka'_Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
- published: 02 Nov 2012
- views: 2447
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
- Order: Reorder
- Duration: 51:39
- Updated: 23 Mar 2010
- views: 16571
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only d...
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
https://wn.com/Robert_Lefkowitz_(Duke_University)_Part_2_Beta_Arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 of the lecture, recent discoveries about how Beta-arrestins not only desensitize the receptors but also mediate their endocytosis, as well as independent signaling pathways, are reviewed. Also covered is how these new discoveries provide a basis for designing novel classes of pharmacological agents which can promote signaling exclusively down either the G protein or Beta-arrestin mediated pathways, so called biased agonists. See more at www.ibiology.org
- published: 23 Mar 2010
- views: 16571
Receptor Basics - Robert Lefkowitz (Duke University)
- Order: Reorder
- Duration: 4:47
- Updated: 16 Nov 2013
- views: 264
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling path...
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
https://wn.com/Receptor_Basics_Robert_Lefkowitz_(Duke_University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introduces the seven transmembrane receptor and its classical signaling pathway.
- published: 16 Nov 2013
- views: 264
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
- Order: Reorder
- Duration: 1:02:20
- Updated: 18 Dec 2012
- views: 4497
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 Decembe...
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
https://wn.com/Nobel_Laureate_In_Chemistry_Professor_Robert_J._Lefkowitz_Nobel_Lecture_At_Uppsala_University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
- published: 18 Dec 2012
- views: 4497
Robert Lefkowitz receives Nobel Prize
- Order: Reorder
- Duration: 1:16
- Updated: 11 Dec 2012
- views: 3085
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobe...
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobel Media AB
source: http://Nobelprize.org
https://wn.com/Robert_Lefkowitz_Receives_Nobel_Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's Nobel Prize in Chemistry. Stockholm, Sweden, December 10, 2012
© Nobel Media AB
source: http://Nobelprize.org
- published: 11 Dec 2012
- views: 3085
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
- Order: Reorder
- Duration: 58:03
- Updated: 19 Mar 2013
- views: 711
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC Scho...
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
https://wn.com/The_Reluctant_Scientist_Keynote_Address_By_Dr._Robert_Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 2013 North Carolina Student Academy of Science conference held at NC School of Science and Math. Lefkowitz and Dr. Brian Kobilka, a former postdoctoral fellow at Duke who worked under Lefkowitz, received the Nobel Prize for their research on G-protein coupled protein receptors, research which has led to major advancements in the development of prescription drugs for a variety of issues ranging from allergies to coronary disease. This keynote address, entitled "The Reluctant Scientist," explores Lefkowitz's journey through childhood, medicine, and science, and the lessons he learned that got him to where he is today. This lecture is hosted by the N.C. Student Academy of Science, a state-wide science education organization for students in grades 6-12, in alliance with the North Carolina Academy of Science that provides opportunities for students to share their research through competition.
NCSSM, a publicly funded high school in North Carolina, provides exciting, high-level STEM learning opportunities. If you appreciate this video, please consider making a tax-deductible donation to the NCSSM Foundation. Thank you! https://connections.ncssm.edu/giving
Please attribute this work as being created by the North Carolina School of Science and Mathematics. This work is licensed under creative commons CC-BY http://creativecommons.org/licenses/by/3.0/
Help us caption & translate this video!
http://amara.org/v/GAco/
- published: 19 Mar 2013
- views: 711
Dr. Robert Lefkowitz: Failure is an ever-present companion
- Order: Reorder
- Duration: 1:58
- Updated: 17 May 2017
- views: 18
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hugh...
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford.
www.gopowerforward.com
www.gopowerforward.com/blog
https://wn.com/Dr._Robert_Lefkowitz_Failure_Is_An_Ever_Present_Companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemistry at Duke University. He has been an Investigator of the Howard Hughes Medical Institute since 1976. He was the 2012 Nobel Laureate in Chemistry, a prize he shared with his former trainee Dr. Brian Kobilka, who is currently a Professor at Stanford.
www.gopowerforward.com
www.gopowerforward.com/blog
- published: 17 May 2017
- views: 18
GPCR signaling - Robert Lefkowitz (Duke)
- Order: Reorder
- Duration: 4:50
- Updated: 16 Nov 2013
- views: 4590
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
https://wn.com/Gpcr_Signaling_Robert_Lefkowitz_(Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description of beta-arrestins role in the signaling pathway.
- published: 16 Nov 2013
- views: 4590
-
Lefkowitz Robert 2014 MasterEdit
published: 26 Mar 2016 -
Mayo Clinic School of Medicine Commencement 2017
Watch the Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences Commencement 2017. Medical students receiving their M.D. degrees and dual M.D./Ph.D. degrees. Along with Graduate students receiving their Ph.D. degrees. #MayoClinicGrad Commencement speaker Nobel Laureate Robert Lefkowitz, M.D. received the degree of Doctor of Science, honoris causa.
published: 22 May 2017 -
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
published: 02 Nov 2012 -
-
Keeping Linux Great
Robert M. "r0ml" Lefkowitz http://linux.conf.au/schedule/presentation/107/ Linux is Great. And part of that greatness was, at one time, attributable to the ascendency of Free Software. Now that Free Software is in decline, it behooves us to reflect upon how to keep Linux great *despite* the fact that it is Free Software. The underlying motivation for Linux and Free Software was (and is) to democratize software -- making it more accessible to all. Free Software used to be the best strategy for doing so. Now that the challenges for democratization have mutated, we must figure out new strategies for democratizing software, and keeping Linux great. This talk will review the changes in the technology environment that have led to the decline of free software, and the emerging opportuni...
published: 21 Jan 2017 -
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
published: 30 Jul 2012 -
Literacy: The Shift from Reading to Writing - Robert "r0ml" Lefkowitz
From OSCON 2013: Robert "r0ml" Lefkowitz (Sharewave) presents how throughout history, the virtue of literacy has been in reading. Reading was the gateway to knowledge, and as a society, we valued literacy because of the uplifting power of reading. Within the last fifty years, a cultural shift began, led by the free software movement, which started to move the locus of virtue in literacy from reading to writing. This shift is seen not only in open source development, but also social media in all its forms. In fact, one can argue that the defining difference between pre-social media and social media is the rise in the importance of writing relative to reading. The implications of this shift are as profound as the transition from orality to literacy. Don't miss an upload! Subscribe! http://g...
published: 04 Jun 2014 -
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012. For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates. http://www.uu.se
published: 18 Dec 2012 -
Lefkowitz Responds to Winning Nobel Prize in Chemistry
At a press conference Oct. 10, 2012, at the Duke University School of Nursing, Dr. Robert Lefkowitz reacts to the announcement that morning that he was awarded the Nobel Prize in Chemistry along with Stanford's Brian Kobilka. Lefkowitz is a professor of biochemistry, immunology and medicine at Duke, and also a basic research cardiologist in the Duke Heart Center. He is a Howard Hughes Medical Institute investigator. Learn more here: http://spotlight.duke.edu/lefkowitz.
published: 12 Dec 2012 -
Unlocking the Secrets of Our Cells: The nobel prize
This half hour documentary recognises four scientists whose work has enabled huge leaps forward in our understanding of medical research: 2012 Chemistry Laureates Robert J. Lefkowitz and Brian K. Kobilka and 2012 Medicine Laureates Sir John B. Gurdon and Shinya Yamanaka. The Laureates talk about their background, their work, and the story behind their groundbreaking research. Leading scientists explain how this work has influenced them, and patients tell us how they have been helped by these medical developments. Credits: Blakeway Productions Copyright © Nobel Media AB 2012 Retrieved from: http://www.nobelprize.org/mediaplayer/index.php?id=1781 Help us caption & translate this video! http://amara.org/v/GgiM/
published: 04 May 2015
Lefkowitz Robert 2014 MasterEdit
- Order: Reorder
- Duration: 58:37
- Updated: 26 Mar 2016
- views: 15
- published: 26 Mar 2016
- views: 15
Mayo Clinic School of Medicine Commencement 2017
- Order: Reorder
- Duration: 1:32:25
- Updated: 22 May 2017
- views: 222
Watch the Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences Commencement 2017. Medical students receiving their M.D. degrees...
Watch the Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences Commencement 2017. Medical students receiving their M.D. degrees and dual M.D./Ph.D. degrees. Along with Graduate students receiving their Ph.D. degrees. #MayoClinicGrad
Commencement speaker Nobel Laureate Robert Lefkowitz, M.D. received the degree of Doctor of Science, honoris causa.
https://wn.com/Mayo_Clinic_School_Of_Medicine_Commencement_2017
Watch the Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences Commencement 2017. Medical students receiving their M.D. degrees and dual M.D./Ph.D. degrees. Along with Graduate students receiving their Ph.D. degrees. #MayoClinicGrad
Commencement speaker Nobel Laureate Robert Lefkowitz, M.D. received the degree of Doctor of Science, honoris causa.
- published: 22 May 2017
- views: 222
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
- Order: Reorder
- Duration: 59:57
- Updated: 02 Nov 2012
- views: 2447
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke...
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
https://wn.com/Dr._Robert_Lefkowitz_On_Science,_Life_And_'Eureka'_Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approach to science and life in a public conversation Nov. 1, 2012, with Duke University President Richard H. Brodhead. Lefkowitz is a Howard Hughes Medical Institute investigator who has spent his entire 39-year research career at the Duke University Medical Center. Learn more here: http://spotlight.duke.edu/lefkowitz.
- published: 02 Nov 2012
- views: 2447
Literacy, Programming, and Open Source por Robert M Lefkowitz - PyCon 2013
- Order: Reorder
- Duration: 1:14:34
- Updated: 08 Nov 2013
- views: 377
Keeping Linux Great
- Order: Reorder
- Duration: 52:09
- Updated: 21 Jan 2017
- views: 5987
Robert M. "r0ml" Lefkowitz
http://linux.conf.au/schedule/presentation/107/
Linux is Great. And part of that greatness was, at one time, attributable to the asc...
Robert M. "r0ml" Lefkowitz
http://linux.conf.au/schedule/presentation/107/
Linux is Great. And part of that greatness was, at one time, attributable to the ascendency of Free Software. Now that Free Software is in decline, it behooves us to reflect upon how to keep Linux great *despite* the fact that it is Free Software.
The underlying motivation for Linux and Free Software was (and is) to democratize software -- making it more accessible to all. Free Software used to be the best strategy for doing so. Now that the challenges for democratization have mutated, we must figure out new strategies for democratizing software, and keeping Linux great.
This talk will review the changes in the technology environment that have led to the decline of free software, and the emerging opportunities for democratizing the software of the future.
https://wn.com/Keeping_Linux_Great
Robert M. "r0ml" Lefkowitz
http://linux.conf.au/schedule/presentation/107/
Linux is Great. And part of that greatness was, at one time, attributable to the ascendency of Free Software. Now that Free Software is in decline, it behooves us to reflect upon how to keep Linux great *despite* the fact that it is Free Software.
The underlying motivation for Linux and Free Software was (and is) to democratize software -- making it more accessible to all. Free Software used to be the best strategy for doing so. Now that the challenges for democratization have mutated, we must figure out new strategies for democratizing software, and keeping Linux great.
This talk will review the changes in the technology environment that have led to the decline of free software, and the emerging opportunities for democratizing the software of the future.
- published: 21 Jan 2017
- views: 5987
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
- Order: Reorder
- Duration: 48:27
- Updated: 30 Jul 2012
- views: 3569
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known f...
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
https://wn.com/Jci's_Conversation_With_Giants_In_Medicine_Robert_Lefkowitz,_Joseph_Goldstein,_And_Michael_Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.
- published: 30 Jul 2012
- views: 3569
Literacy: The Shift from Reading to Writing - Robert "r0ml" Lefkowitz
- Order: Reorder
- Duration: 43:14
- Updated: 04 Jun 2014
- views: 1807
From OSCON 2013: Robert "r0ml" Lefkowitz (Sharewave) presents how throughout history, the virtue of literacy has been in reading. Reading was the gateway to kno...
From OSCON 2013: Robert "r0ml" Lefkowitz (Sharewave) presents how throughout history, the virtue of literacy has been in reading. Reading was the gateway to knowledge, and as a society, we valued literacy because of the uplifting power of reading. Within the last fifty years, a cultural shift began, led by the free software movement, which started to move the locus of virtue in literacy from reading to writing. This shift is seen not only in open source development, but also social media in all its forms. In fact, one can argue that the defining difference between pre-social media and social media is the rise in the importance of writing relative to reading. The implications of this shift are as profound as the transition from orality to literacy.
Don't miss an upload! Subscribe! http://goo.gl/szEauh
Stay Connected to O'Reilly Media by Email - http://goo.gl/YZSWbO
Follow O'Reilly Media:
http://plus.google.com/+oreillymedia
https://www.facebook.com/OReilly
https://twitter.com/OReillyMedia
https://wn.com/Literacy_The_Shift_From_Reading_To_Writing_Robert_R0Ml_Lefkowitz
From OSCON 2013: Robert "r0ml" Lefkowitz (Sharewave) presents how throughout history, the virtue of literacy has been in reading. Reading was the gateway to knowledge, and as a society, we valued literacy because of the uplifting power of reading. Within the last fifty years, a cultural shift began, led by the free software movement, which started to move the locus of virtue in literacy from reading to writing. This shift is seen not only in open source development, but also social media in all its forms. In fact, one can argue that the defining difference between pre-social media and social media is the rise in the importance of writing relative to reading. The implications of this shift are as profound as the transition from orality to literacy.
Don't miss an upload! Subscribe! http://goo.gl/szEauh
Stay Connected to O'Reilly Media by Email - http://goo.gl/YZSWbO
Follow O'Reilly Media:
http://plus.google.com/+oreillymedia
https://www.facebook.com/OReilly
https://twitter.com/OReillyMedia
- published: 04 Jun 2014
- views: 1807
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
- Order: Reorder
- Duration: 1:02:20
- Updated: 18 Dec 2012
- views: 4499
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 Decembe...
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
https://wn.com/Nobel_Laureate_In_Chemistry_Professor_Robert_J._Lefkowitz_Nobel_Lecture_At_Uppsala_University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Protein Coupled Receptors" - Nobel Lecture at Uppsala Univesity 13 December 2012.
For many years it has been a tradition to invite the new Nobel Prize laureates to Uppsala University in connection with the Nobel Prize festivities in Stockholm. The program for the visit includes a reception with the Vice Chancellor and lunch at Uppsala Castle, but also much appreciated and well-attended open lectures by the guest laureates.
http://www.uu.se
- published: 18 Dec 2012
- views: 4499
Lefkowitz Responds to Winning Nobel Prize in Chemistry
- Order: Reorder
- Duration: 47:24
- Updated: 12 Dec 2012
- views: 1008
At a press conference Oct. 10, 2012, at the Duke University School of Nursing, Dr. Robert Lefkowitz reacts to the announcement that morning that he was awarded ...
At a press conference Oct. 10, 2012, at the Duke University School of Nursing, Dr. Robert Lefkowitz reacts to the announcement that morning that he was awarded the Nobel Prize in Chemistry along with Stanford's Brian Kobilka. Lefkowitz is a professor of biochemistry, immunology and medicine at Duke, and also a basic research cardiologist in the Duke Heart Center. He is a Howard Hughes Medical Institute investigator. Learn more here: http://spotlight.duke.edu/lefkowitz.
https://wn.com/Lefkowitz_Responds_To_Winning_Nobel_Prize_In_Chemistry
At a press conference Oct. 10, 2012, at the Duke University School of Nursing, Dr. Robert Lefkowitz reacts to the announcement that morning that he was awarded the Nobel Prize in Chemistry along with Stanford's Brian Kobilka. Lefkowitz is a professor of biochemistry, immunology and medicine at Duke, and also a basic research cardiologist in the Duke Heart Center. He is a Howard Hughes Medical Institute investigator. Learn more here: http://spotlight.duke.edu/lefkowitz.
- published: 12 Dec 2012
- views: 1008
Unlocking the Secrets of Our Cells: The nobel prize
- Order: Reorder
- Duration: 30:16
- Updated: 04 May 2015
- views: 1658
This half hour documentary recognises four scientists whose work has enabled huge leaps forward in our understanding of medical research: 2012 Chemistry Laureat...
This half hour documentary recognises four scientists whose work has enabled huge leaps forward in our understanding of medical research: 2012 Chemistry Laureates Robert J. Lefkowitz and Brian K. Kobilka and 2012 Medicine Laureates Sir John B. Gurdon and Shinya Yamanaka. The Laureates talk about their background, their work, and the story behind their groundbreaking research. Leading scientists explain how this work has influenced them, and patients tell us how they have been helped by these medical developments.
Credits: Blakeway Productions
Copyright © Nobel Media AB 2012
Retrieved from: http://www.nobelprize.org/mediaplayer/index.php?id=1781
Help us caption & translate this video!
http://amara.org/v/GgiM/
https://wn.com/Unlocking_The_Secrets_Of_Our_Cells_The_Nobel_Prize
This half hour documentary recognises four scientists whose work has enabled huge leaps forward in our understanding of medical research: 2012 Chemistry Laureates Robert J. Lefkowitz and Brian K. Kobilka and 2012 Medicine Laureates Sir John B. Gurdon and Shinya Yamanaka. The Laureates talk about their background, their work, and the story behind their groundbreaking research. Leading scientists explain how this work has influenced them, and patients tell us how they have been helped by these medical developments.
Credits: Blakeway Productions
Copyright © Nobel Media AB 2012
Retrieved from: http://www.nobelprize.org/mediaplayer/index.php?id=1781
Help us caption & translate this video!
http://amara.org/v/GgiM/
- published: 04 May 2015
- views: 1658
- Playlist
- Chat
55:15
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the fir...
published: 23 Mar 2010
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
- Report rights infringement
- published: 23 Mar 2010
- views: 40652
2:47
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who...
published: 10 Oct 2012
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Report rights infringement
- published: 10 Oct 2012
- views: 7433
59:57
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approac...
published: 02 Nov 2012
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
- Report rights infringement
- published: 02 Nov 2012
- views: 2447
51:39
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 ...
published: 23 Mar 2010
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
- Report rights infringement
- published: 23 Mar 2010
- views: 16571
4:47
Receptor Basics - Robert Lefkowitz (Duke University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introd...
published: 16 Nov 2013
Receptor Basics - Robert Lefkowitz (Duke University)
Receptor Basics - Robert Lefkowitz (Duke University)
- Report rights infringement
- published: 16 Nov 2013
- views: 264
1:02:20
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Prot...
published: 18 Dec 2012
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
- Report rights infringement
- published: 18 Dec 2012
- views: 4497
1:16
Robert Lefkowitz receives Nobel Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's ...
published: 11 Dec 2012
Robert Lefkowitz receives Nobel Prize
Robert Lefkowitz receives Nobel Prize
- Report rights infringement
- published: 11 Dec 2012
- views: 3085
58:03
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 201...
published: 19 Mar 2013
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
- Report rights infringement
- published: 19 Mar 2013
- views: 711
1:58
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemis...
published: 17 May 2017
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz: Failure is an ever-present companion
- Report rights infringement
- published: 17 May 2017
- views: 18
4:50
GPCR signaling - Robert Lefkowitz (Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description ...
published: 16 Nov 2013
GPCR signaling - Robert Lefkowitz (Duke)
GPCR signaling - Robert Lefkowitz (Duke)
- Report rights infringement
- published: 16 Nov 2013
- views: 4590
- Playlist
- Chat
6:20
Robert J. Lefkowitz interview: Nobel Prize in Chemistry 2012
Telephone interview with Robert J. Lefkowitz following the announcement of the 2012 Nobel ...
published: 11 Oct 2012
Robert J. Lefkowitz interview: Nobel Prize in Chemistry 2012
Robert J. Lefkowitz interview: Nobel Prize in Chemistry 2012
- Report rights infringement
- published: 11 Oct 2012
- views: 824
8:06
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 1 of 2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has w...
published: 02 Aug 2011
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 1 of 2
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 1 of 2
- Report rights infringement
- published: 02 Aug 2011
- views: 255
5:20
Interview with Robert J. Lefkowitz, 2009 Frontiers of Knowledge Award in Biomedicine
Interview with Prof. Robert J. Lefkowitz, winner of the 2009 BBVA Foundation Frontiers of ...
published: 28 Jun 2017
Interview with Robert J. Lefkowitz, 2009 Frontiers of Knowledge Award in Biomedicine
Interview with Robert J. Lefkowitz, 2009 Frontiers of Knowledge Award in Biomedicine
- Report rights infringement
- published: 28 Jun 2017
- views: 2
9:27
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 2 of 2
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has w...
published: 02 Aug 2011
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 2 of 2
David Mertz interviews from OSCON 2011: Robert Lefkowitz, Part 2 of 2
- Report rights infringement
- published: 02 Aug 2011
- views: 125
2:47
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who...
published: 10 Oct 2012
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Report rights infringement
- published: 10 Oct 2012
- views: 7433
8:04
Robert "r0ml" Lefkowitz interviewed at OSCON 2013
Robert (a/k/a r0ml) Lefkowitz is a computer professional and amateur philosopher. He has w...
published: 31 Jul 2013
Robert "r0ml" Lefkowitz interviewed at OSCON 2013
Robert "r0ml" Lefkowitz interviewed at OSCON 2013
- Report rights infringement
- published: 31 Jul 2013
- views: 272
9:37
David Mertz interviews Robert Lefkowitz for IBM's developerWorks, Part 2
David Mertz conducted a series of interviews with Robert Lefkowitz for IBM's developerWork...
published: 15 Feb 2013
David Mertz interviews Robert Lefkowitz for IBM's developerWorks, Part 2
David Mertz interviews Robert Lefkowitz for IBM's developerWorks, Part 2
- Report rights infringement
- published: 15 Feb 2013
- views: 24
1:03
Lefkowitz on fundamental, translational, and clinical research.
Duke University's President Richard H. Brodhead interviews Dr. Robert Lefkowitz, a 2012 No...
published: 09 Sep 2014
Lefkowitz on fundamental, translational, and clinical research.
Lefkowitz on fundamental, translational, and clinical research.
- Report rights infringement
- published: 09 Sep 2014
- views: 57
58:03
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 201...
published: 19 Mar 2013
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
- Report rights infringement
- published: 19 Mar 2013
- views: 711
48:27
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Micha...
published: 30 Jul 2012
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
- Report rights infringement
- published: 30 Jul 2012
- views: 3569
- Playlist
- Chat
55:15
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-1.html
In the fir...
published: 23 Mar 2010
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
Robert Lefkowitz (Duke University) Part 1 Seven Transmembrane Receptors
- Report rights infringement
- published: 23 Mar 2010
- views: 40652
2:47
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
DURHAM, N.C. -- Robert J. Lefkowitz MD, a Howard Hughes Medical Institute investigator who...
published: 10 Oct 2012
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
Duke's Robert Lefkowitz shares in chemistry Nobel Prize
- Report rights infringement
- published: 10 Oct 2012
- views: 7433
59:57
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approac...
published: 02 Nov 2012
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
- Report rights infringement
- published: 02 Nov 2012
- views: 2447
51:39
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
http://www.ibiology.org/ibioseminars/cell-biology/robert-lefkowitz-part-2.html
In part 2 ...
published: 23 Mar 2010
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
Robert Lefkowitz (Duke University) Part 2 Beta-arrestins
- Report rights infringement
- published: 23 Mar 2010
- views: 16571
4:47
Receptor Basics - Robert Lefkowitz (Duke University)
Robert Lefkowitz gives background on receptors and how they are activated. He also introd...
published: 16 Nov 2013
Receptor Basics - Robert Lefkowitz (Duke University)
Receptor Basics - Robert Lefkowitz (Duke University)
- Report rights infringement
- published: 16 Nov 2013
- views: 264
1:02:20
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Prot...
published: 18 Dec 2012
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
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- published: 18 Dec 2012
- views: 4497
1:16
Robert Lefkowitz receives Nobel Prize
Duke's Robert J. Lefkowitz, MD, James B. Duke Professor of Medicine, receives this year's ...
published: 11 Dec 2012
Robert Lefkowitz receives Nobel Prize
Robert Lefkowitz receives Nobel Prize
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- published: 11 Dec 2012
- views: 3085
58:03
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
Nobel Prize winning professor Dr. Robert Lefkowitz delivers his keynote address at the 201...
published: 19 Mar 2013
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
"The Reluctant Scientist" - Keynote Address by Dr. Robert Lefkowitz
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- published: 19 Mar 2013
- views: 711
1:58
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz is the James B. Duke Professor of Medicine and Professor of Biochemis...
published: 17 May 2017
Dr. Robert Lefkowitz: Failure is an ever-present companion
Dr. Robert Lefkowitz: Failure is an ever-present companion
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- published: 17 May 2017
- views: 18
4:50
GPCR signaling - Robert Lefkowitz (Duke)
The classical signaling paradigm for G-protein coupled-receptors, and a brief description ...
published: 16 Nov 2013
GPCR signaling - Robert Lefkowitz (Duke)
GPCR signaling - Robert Lefkowitz (Duke)
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- published: 16 Nov 2013
- views: 4590
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58:37
Lefkowitz Robert 2014 MasterEdit
published: 26 Mar 2016
Lefkowitz Robert 2014 MasterEdit
Lefkowitz Robert 2014 MasterEdit
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- published: 26 Mar 2016
- views: 15
1:32:25
Mayo Clinic School of Medicine Commencement 2017
Watch the Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sci...
published: 22 May 2017
Mayo Clinic School of Medicine Commencement 2017
Mayo Clinic School of Medicine Commencement 2017
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- published: 22 May 2017
- views: 222
59:57
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz, a winner of the 2012 Nobel Prize in Chemistry, discusses his approac...
published: 02 Nov 2012
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
Dr. Robert Lefkowitz on Science, Life and 'Eureka' Moments
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- published: 02 Nov 2012
- views: 2447
1:14:34
Literacy, Programming, and Open Source por Robert M Lefkowitz - PyCon 2013
Help us caption & translate this video!
http://amara.org/v/DK6A/
published: 08 Nov 2013
Literacy, Programming, and Open Source por Robert M Lefkowitz - PyCon 2013
Literacy, Programming, and Open Source por Robert M Lefkowitz - PyCon 2013
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- published: 08 Nov 2013
- views: 377
52:09
Keeping Linux Great
Robert M. "r0ml" Lefkowitz
http://linux.conf.au/schedule/presentation/107/
Linux is Great....
published: 21 Jan 2017
Keeping Linux Great
Keeping Linux Great
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- published: 21 Jan 2017
- views: 5987
48:27
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
Three of medicine's most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Micha...
published: 30 Jul 2012
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
JCI's Conversation with Giants in Medicine: Robert Lefkowitz, Joseph Goldstein, and Michael Brown
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- published: 30 Jul 2012
- views: 3569
43:14
Literacy: The Shift from Reading to Writing - Robert "r0ml" Lefkowitz
From OSCON 2013: Robert "r0ml" Lefkowitz (Sharewave) presents how throughout history, the ...
published: 04 Jun 2014
Literacy: The Shift from Reading to Writing - Robert "r0ml" Lefkowitz
Literacy: The Shift from Reading to Writing - Robert "r0ml" Lefkowitz
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- published: 04 Jun 2014
- views: 1807
1:02:20
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
2012 Nobel Laureate in Chemistry Professor Robert J. Lefkowitz "A Brief History of G-Prot...
published: 18 Dec 2012
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
Nobel Laureate in Chemistry - Professor Robert J. Lefkowitz - Nobel Lecture at Uppsala University
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- published: 18 Dec 2012
- views: 4499
47:24
Lefkowitz Responds to Winning Nobel Prize in Chemistry
At a press conference Oct. 10, 2012, at the Duke University School of Nursing, Dr. Robert ...
published: 12 Dec 2012
Lefkowitz Responds to Winning Nobel Prize in Chemistry
Lefkowitz Responds to Winning Nobel Prize in Chemistry
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- published: 12 Dec 2012
- views: 1008
30:16
Unlocking the Secrets of Our Cells: The nobel prize
This half hour documentary recognises four scientists whose work has enabled huge leaps fo...
published: 04 May 2015
Unlocking the Secrets of Our Cells: The nobel prize
Unlocking the Secrets of Our Cells: The nobel prize
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- published: 04 May 2015
- views: 1658
Lefkowitz Robert 2014 MasterEdit...
Mayo Clinic School of Medicine Commencement 2017...
Dr. Robert Lefkowitz on Science, Life and 'Eureka'...
Literacy, Programming, and Open Source por Robert ...
Keeping Linux Great...
JCI's Conversation with Giants in Medicine: Robert...
Literacy: The Shift from Reading to Writing - Robe...
Nobel Laureate in Chemistry - Professor Robert J. ...
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Democrats Working Behind The Scenes On 25th Amendment Measure To Oust Trump
Edit WorldNews.com 05 Jul 2017
A move is afoot in the halls of Congress, in cloakrooms and on the floor of the U.S. House of Representatives to support a bill to create a congressional “oversight” commission to declare U.S. President Donald Trump incapacitated, leading to his removal from office under the U.S. Constitution’s 25th Amendment, Yahoo News reported ... government officials....
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Report: ISIS Recruiter Sally Jones 'Wants To Return To Britain' From War-Torn Raqqa
Edit WorldNews.com 05 Jul 2017
Sally Jones, the Islamic State group’s iconic poster girl, who goes by the nom de guerre Mrs. Terror, is desperate to return to the UK, a published report said earlier this week, on the day U.S.-backed forces made a major breakthrough in the battle for the group’s operational capital Raqqa, The International Business Times reported ... “She was crying and wants to get back to Britain. She told me she wish [sic] to go to her country....
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'A gift for the American bastards': North Korea's Kim fires back at Trump
Edit The Guardian 05 Jul 2017
Kim Jong-un saw the opportunity for maximum mischief offered by the most auspicious date in US history to launch a missile, literally and verbally. North Korea. 'A gift for the American bastards'. North Korea's Kim fires back at Trump ... Read more ... Twitter ... “Kim Jong-il’s legacy was mixed – he let the army run the country for 10 years because he was afraid of a coup,” said Robert Kelly, a North Korea expert at Pusan National University ... ....
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Investigators Claim Long-Lost Photo Shows Amelia Earhart Alive After Her Plane Vanished
Edit WorldNews.com 05 Jul 2017
A new documentary claims a photo from 1937 discovered in the National Archives shows aviator Amelia Earhart and navigator Fred Noonan in Japanese custody, indicating the pair might have survived after their plane disappeared over the Pacific Ocean, CBS News reports.Airing Sunday on the History channel, “Amelia Earhart ... They vanished without a trace, spurring the largest and most expensive search and rescue effort by the U.S....
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Trump Supporters Thought NPR Tweeting the Declaration of Independence Was Propaganda
Edit WorldNews.com 06 Jul 2017
In a tradition that's been ongoing for 29 years, National Public Radio decided to bring their annual reading of the Declaration of Independence to their main Twitter account line by line on Tuesday but things quickly went array, according to The Washington Post ... Many tweets directed at NPR accused the account of spam or trying to push an agenda at overthrowing the current administration of President Donald Trump ... ....
Dr. Robert Scott, Carroll-based orthodontist, remembered as 'a powerful force in the community'
Edit Baltimore Sun 06 Jul 2017
Decades ago, Carolyn Scott bought her husband, Dr. Robert "Bob" Scott, 40 grapevines as a present. He created a vineyard on the hill alongside their house — a location, Carolyn recalls Robert Scott saying was perfect for growing grapes — and sold some of them to commercial wineries. He even made... ....
UFC 213: Robert Whittaker works out for fans before biggest fight of his life
Edit Sydney Morning Herald 06 Jul 2017Robert Mueller's growing special counsel team is coming under scrutiny
Edit The Providence Journal 06 Jul 2017Judge: Robert Durst's friends must testify at murder hearing
Edit San Francisco Chronicle 06 Jul 2017
MINEOLA, N.Y. (AP) — Two of Robert Durst's longtime friends have been ordered by a New York judge to testify at a pretrial hearing in the eccentric millionaire's murder case in California this month. Durst, who was featured in the HBO documentary "The Jinx," is facing murder charges in Los Angeles in the 2000 killing of his longtime friend, Susan Berman ... ....
Yoel Romero: Robert Whittaker Prepared for This; I Was Made for This
Edit Sherdog 06 Jul 2017
Yoel Romero talks about his showdown with Robert Whittaker at UFC 213 ... ....
Robert Whittaker: How I’m Going to Defeat Yoel Romero at UFC 213
Edit Sherdog 06 Jul 2017
Robert Whittaker breaks down the tale of the tape against Yoel Romero at UFC 213 ... ....
Robert Whittaker previews his UFC 213 fight with Yoel Romero | UFC TONIGHT
Edit Fox Sports 06 Jul 2017
Robert Whittaker talks with Kenny Florian and Michael Bisping about his upcoming UFC 213 fight with Yoel Romero ... ....
Spider-Man: Homecoming movie review – Tom Holland and Robert Downey Jr starrer is the web slinger we were waiting for all these years
Edit Bollywood Life 06 Jul 2017
Robert Downey Jr ... Homecoming and it was revealed that will also feature MCU’s poster boy since its inception in 2008, Robert Downey Jr aka Iron Man aka Tony Stark ... And what can I say about the truly invincible Iron Man aka Robert Downey Jr ... Captain America Chris Evans reveals, Robert Downey Jr may quit Iron Man sooner than you expect ... Robert Downey Jr....
Roberts: Tom Horne is (sort of) vindicated
Edit The Arizona Republic 06 Jul 2017
The Cochise County attorney has cleared Tom Horne of illegal conduct. Don't look for a political comeback, though ... ....
Kershaw makes tough decision to miss ASG
Edit MLB 06 Jul 2017
LOS ANGELES -- Dodgers manager Dave Roberts said ace Clayton Kershaw will make his next start on Sunday, which would take him out of pitching in the MLB All-Star Game presented by Mastercard on July 11 ... "We talked to Clayton and he's made it very clear that his priority is the Dodgers," Roberts said ... "He's very deserving," Roberts said about Wood....
Kershaw won't pitch in All-Star Game
Edit MLB 06 Jul 2017
LOS ANGELES -- Dodgers manager Dave Roberts said ace Clayton Kershaw will make his next start on Sunday, which would take him out of pitching in the MLB All-Star Game presented by Mastercard on July 11 ... Roberts met with Kershaw and discussed the possibility of changing the rotation around, but ultimately came to the decision for Kershaw to make his scheduled start against the Royals, Roberts said....
Marriage Equality May Soon Be in Peril
Edit Slate 06 Jul 2017
Before Obergefell , some commentators ( myself included ) speculated that Chief Justice John Roberts might recognize the malice inherent in same-sex marriage bans and strike them down ... Roberts’ Obergefell dissent was noxious and cruel , instructing same-sex couples not to “celebrate the Constitution” because it “had nothing to do with” the ruling ... If Kennedy retires, Roberts will become the swing vote on marriage equality....
Viking Cruises founder and estranged wife hug after reaching divorce settlement
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