Kanchipuram

Kanchipuram otherwise known as Kanchi (previously romanized as Kāñci-pura, Conjevaram) is a city in the Indian state of Tamil Nadu, 72 km (45 mi) from Chennai – the capital of Tamil Nadu. The city covers an area of 11.605 km² (4.481 sq mi) and had a population of 164,265 in 2001. It is the administrative headquarters of Kanchipuram District. Kanchipuram is well-connected by road and rail. Chennai International Airport is the nearest domestic and international airport to the city, which is located at Tirusulam in Kanchipuram district.

Located on the banks of the Vegavathy River, Kanchipuram has been ruled by the Pallavas, the Medieval Cholas, the Later Cholas, the Later Pandyas, the Vijayanagar Empire, the Carnatic kingdom, and the British. The city's historical monuments include the Kailasanathar Temple and the Vaikunta Perumal Temple. Historically, Kanchipuram was a centre of education and was known as the ghatikasthanam, or "place of learning". The city was also a religious centre of advanced education for Jainism and Buddhism between the 1st and 5th centuries.

Piano Sonata No. 13 (Mozart)

The Piano Sonata in B-flat major, K. 333 (315c), was composed by Wolfgang Amadeus Mozart in Linz at the end of 1783.

Dating

There is no doubt that this sonata was first published on April 21, 1784 in Vienna by Christoph Torricella (along with K. 284 and K. 454, as op. 7). The actual date of composition, however, has proved more difficult to determine. Because the manuscript is not written on the type of music paper Mozart is known to have used in Vienna, scholars believed that the piece was composed before Mozart moved to that city. Thus Köchel, in the first edition of his Mozart catalog (1862), gave the hypothetical date 1779, later clarified by Georges de Saint-Foix (1936) to "Salzburg, beginning of January–March 1779." However, Alfred Einstein, in the third edition of the Köchel catalog (1937), said that it was composed in "late summer 1778 in Paris." This date was maintained even until the sixth edition of the Köchel catalog (1964).

More recently, this date has been invalidated by the findings of Wolfgang Plath and Alan Tyson. On the basis of Mozart's script, Plath assigns the piece to the time around 1783/84, "likely not long before the appearance of the first print." Furthermore, Tyson convincingly demonstrates through paper tests that the work was composed at the end of 1783, likely in November, around the same time as the "Linz Symphony", K. 425, when the Mozart couple made a stopover in Linz on their way back to Vienna from Salzburg. This new dating also fits stylistic criteria.

Andromeda Galaxy

The Andromeda Galaxy (/ænˈdrɒmᵻdə/), also known as Messier 31, M31, or NGC 224, is a spiral galaxy approximately 780 kiloparsecs (2.5 million light-years) from Earth. It is the nearest major galaxy to the Milky Way and was often referred to as the Great Andromeda Nebula in older texts. It received its name from the area of the sky in which it appears, the constellation of Andromeda, which was named after the mythological princess Andromeda. Being approximately 220,000 light years across, it is the largest galaxy of the Local Group, which also contains the Milky Way, the Triangulum Galaxy, and about 44 other smaller galaxies.

Despite earlier findings that suggested that the Milky Way contains more dark matter and could be the largest in the grouping, the 2006 observations by the Spitzer Space Telescope revealed that Andromeda contains one trillion (10¹²) stars: at least twice the number of stars in the Milky Way, which is estimated to be 200–400 billion.

The Andromeda Galaxy is estimated to be 1.5×10¹²solar masses, while the mass of the Milky Way is estimated to be 8.5×10¹¹ solar masses. In comparison, a 2009 study estimated that the Milky Way and M31 are about equal in mass, while a 2006 study put the mass of the Milky Way at ~80% of the mass of the Andromeda Galaxy. The Milky Way and Andromeda are expected to collide in 3.75 billion years, eventually merging to form a giant elliptical galaxy or perhaps a large disk galaxy.

Caught

Caught is a method of dismissing a batsman in the sport of cricket. Being caught out is the most common method of dismissal at higher levels of competition. This method of dismissal is covered by Law 32 of the Laws of cricket which reads:

A batsman is out caught if a fielder catches the ball fully within the field of play without it bouncing once the ball has touched the striker's bat or glove holding the bat. If a batsman could be given out caught or by any other method except bowled, 'caught' takes precedence.

This means that the batsman cannot be out caught if:

Charles Messier

Charles Messier (French: [me.sje]; 26 June 1730 – 12 April 1817) was a French astronomer most notable for publishing an astronomical catalogue consisting of nebulae and star clusters that came to be known as the 110 "Messier objects". The purpose of the catalogue was to help astronomical observers, in particular comet hunters such as himself, distinguish between permanent and transient visually diffuse objects in the sky.

Biography

Messier was born in Badonviller in the Lorraine region of France, being the tenth of twelve children of Françoise B. Grandblaise and Nicolas Messier, a Court usher. Six of his brothers and sisters died while young and in 1741, his father died. Charles' interest in astronomy was stimulated by the appearance of the spectacular, great six-tailed comet in 1744 and by an annular solar eclipse visible from his hometown on 25 July 1748.

In 1751 he entered the employ of Joseph Nicolas Delisle, the astronomer of the French Navy, who instructed him to keep careful records of his observations. Messier's first documented observation was that of the Mercury transit of 6 May 1753.

Complement component 5

Complement component 5 is a protein that in humans is encoded by the C5 gene.

Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b:

Deficiency is thought to cause Leiner's disease.

Function

Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.

Clinical significance

Order of the Bath

The Most Honourable Order of the Bath (formerly the Most Honourable Military Order of the Bath) is a British order of chivalry founded by George I on 18 May 1725. The name derives from the elaborate medieval ceremony for creating a knight, which involved bathing (as a symbol of purification) as one of its elements. The knights so created were known as "Knights of the Bath". George I "erected the Knights of the Bath into a regular Military Order". He did not (as is commonly believed) revive the Order of the Bath, since it had never previously existed as an Order, in the sense of a body of knights who were governed by a set of statutes and whose numbers were replenished when vacancies occurred.

The Order consists of the Sovereign (currently Queen Elizabeth II), the Great Master (currently The Prince of Wales), and three Classes of members:

Members belong to either the Civil or the Military Division. Prior to 1815, the order had only a single class, Knight Companion (KB), which no longer exists. Recipients of the Order are now usually senior military officers or senior civil servants. Commonwealth citizens not subjects of the Queen and foreigners may be made Honorary Members.