A person has died at Rio Tinto's Yandicoogina mine site in the Pilbara on Tuesday.
The incident was reported to police around midday, with investigators on their way to the scene - 100 kilometres north of Newman.
Fairfax Media understands the worker died as a result of an explosion.
Police said they believe the deceased is a man aged in his early 50s.
Emergency services will not be releasing any further details until the person's next of kin have been notified.
Rio Tinto confirmed the site has been shut down following the incident.
In a statement a company spokesman said: "An employee at Rio Tinto's Yandicoogina iron ore mine passed away this morning following a serious incident on site.
"Emergency services are on scene. Rio Tinto has advised the relevant authorities and will assist their investigations.
"The company will provide all the necessary support for the employee's family and colleagues during this difficult time."
It's the first death at a WA mine site in a year.
Mine deaths in WA since 2013
July 2016
A man in his 60s died after a bridge collapsed at Central Norseman Gold Mine in the Goldfields.
Lee Buzzard, June 2016
Mr Buzzard died while performing maintenance on a drill head at Rio Tinto's Channar mine near Paraburdoo.
Benjamin White, November 2015
Mr White, a scaffolder, died after falling into a process vessel at Alcoa's Kwinana refinery.
Adam Perttula, November 2015
A 28-year-old jumbo offsider collapsed while working underground on night shift in hot conditions at the Paulsens Gold Mine south of Pannawonica in the Pilbara and died the next day.
Hira Rewita, September 2015
A 56-year-old man was fatally injured when his haul truck rolled over at Cornishman Pit gold mine near Southern Cross.
Joshua Martin, May 2015
Mr Martin was fatally crushed while working at Telfer mine in the Pilbara.
Adam Hardaker, May 2015
Mr Hardaker was fatally struck by a 700 kilogram rock that rolled from an open stope while working at Nifty Copper underground mine in the Pilbara region.
Philip Kitching, January 2015
Mr Kitching was fatally crushed while conducting maintenance work on a bulldozer at Woodie Woodie Manganese mine in the Pilbara region.
Colin Whitton, September 2014
Electrician Mr Whitton was fatally while carrying out maintenance on a lift at BHP's Worsley alumina refinery in Collie.
Lance Farber, May 2014
Mr Farber was fatally crushed when he was trapped between the mast and frame of a forklift truck at Brightstar gold mine near Laverton in the Goldfields.
Wayne Fowlie, February 2014
Mr Fowlie was killed when a six metre wall collapsed on him while he was trying to clean a bogger at Central Norseman Gold's Harlequin underground mine in the Goldfields.
Allen Zuvela, December 2013
Mr Zuvela was fatally crushed while working underneath a 2.5 tonne can which fell from its rigging at FMG's Christmas Creek mine in the Pilbara.
Stephen Hampton, December 2013
Mr Hampton was fatally crushed by a pipe which slid down an embankment and pinned him against a wall at Newcrest's Telfer gold mine in the Pilbara.
Kurt Williams, August 2013
Mr Williams was killed while performing maintenance at an iron ore process facility at FMG's Christmas Creek mine in the Pilbara.
