ABCG2

ATP-binding cassette sub-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338).

Function

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as the Breast Cancer Resistance Protein, this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. Early observations of significant ABCG2-mediated resistance to anthracyclines were subsequently attributed mutations encountered in vitro but not in nature or the clinic. Significant expression of this protein has been observed in the placenta, and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation.

Donald Trump

Donald John Trump, Sr. (born June 14, 1946) is an American businessperson and media personality. He is the chairman and president of The Trump Organization and the founder of Trump Entertainment Resorts. Trump's career, branding efforts, personal life, wealth, and outspoken manner have made him famous throughout the country. Since 2015, he is also a candidate for the Republican nomination for President of the United States in the 2016 election.

Trump is a native of New York City and a son of Fred Trump, who inspired him to enter real estate development. After two years at Fordham University and while studying at Wharton School of the University of Pennsylvania, Trump worked for his father's firm, Elizabeth Trump & Son. Upon graduating in 1968 he joined the company, and in 1971 was given control, renaming the company "The Trump Organization". Since then he has built hotels, golf courses, and other properties, many of which bear his name. He is a major figure in the American business scene and has received prominent media exposure. The NBC reality show The Apprentice bolstered his fame, and his three marriages were extensively reported in tabloids.

Hillary Clinton

Hillary Diane Rodham Clinton (born October 26, 1947) is an American politician and former United States Senator from New York from 2001 to 2009. She is the wife of the 42nd President of the United States William "Bill" Jefferson Clinton, and was First Lady of the United States during his tenure from 1993 to 2001. She served under current President Barack Obama as the 67th United States Secretary of State from 2009 to 2013. She is a candidate for the Democratic nomination for President of the United States in the 2016 presidential election.

A native of the Chicago area, Hillary Rodham graduated from Wellesley College in 1969, where she became the first student commencement speaker. She went on to earn her J.D. from Yale Law School in 1973. After a stint as a congressional legal counsel, she moved to Arkansas, marrying Bill Clinton in 1975. She co-founded Arkansas Advocates for Children and Families in 1977, became the first female chair of the Legal Services Corporation in 1978, and was named the first female partner at Rose Law Firm in 1979. While First Lady of Arkansas from 1979 to 1981, and 1983 to 1992, she led a task force that reformed Arkansas' public school system, and served on the board of directors of Wal-Mart among other corporations.