House (also known as House, M.D.) is an American television medical drama that originally ran on the Fox network from November 16, 2004, to May 21, 2012. The show's central character is Dr. Gregory House (Hugh Laurie), an unconventional and misanthropic medical genius who heads a team of diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital (PPTH) in New Jersey. The show's premise originated with Paul Attanasio, while David Shore, who is credited as creator, was primarily responsible for the conception of the title character. The show's executive producers include Shore, Attanasio, Attanasio's business partner Katie Jacobs, and film director Bryan Singer. It was largely filmed in Century City.

James Hugh Calum Laurie, OBE (born 11 June 1959), known as Hugh Laurie (/ˈhjuː ˈlɒri/), is an English actor, voice artist, comedian, writer, musician, recording artist, and director. He first became known as one half of the Fry and Laurie double act, along with his friend and comedy partner Stephen Fry, whom he joined in the cast of Blackadder and Jeeves and Wooster from 1987 to 1999.

From 2004 to 2012, he played Dr Gregory House, the protagonist of House, for which he received two Golden Globe awards, two Screen Actors Guild awards, and six Emmy nominations. As of August 2010, Laurie is the highest paid actor in a drama series on US television. He has been listed in the 2011 Guinness Book of World Records as the highest paid actor ever in a TV Drama—earning US$ 700,000 per episode in House—and for being the most watched leading man on television.

Laurie was born in Oxford, Oxfordshire, England. The youngest of four children, Laurie has an older brother named Charles and two older sisters named Susan and Janet. He had a somewhat strained relationship with his mother, Patricia (née Laidlaw). His father, Ran Laurie, was a medical doctor who also won an Olympic gold medal in the coxless pairs (rowing) at the 1948 London Games.

Stephen John Fry (born 24 August 1957) is an English actor, screenwriter, author, playwright, journalist, poet, comedian, television presenter, film director, and a director of Norwich City Football Club.

After a troubled childhood and adolescence, during which he was expelled from a number of schools and eventually spent three months in prison for credit card fraud, he was able to secure a place at Queens' College, Cambridge, where he studied English Literature.

He first came to public attention in the 1981 Cambridge Footlights Revue presentation "The Cellar Tapes", which also included Hugh Laurie, Emma Thompson and Tony Slattery. With Hugh Laurie, as the comedy double act Fry and Laurie, he co-wrote and co-starred in A Bit of Fry & Laurie, and took the role of Jeeves (with Laurie playing Wooster) in Jeeves and Wooster.

As an actor, Fry played the lead in the film Wilde, was Melchett in the BBC television series Blackadder, starred as the title character Peter Kingdom in the ITV series Kingdom, has a recurring guest role as Dr. Gordon Wyatt on the Fox crime series Bones and appeared as rogue TV host Gordon Deitrich in the dystopian thriller V For Vendetta. He has also written and presented several documentary series including the 2008 television series Stephen Fry in America, which saw him travelling across all 50 US states. Since 2003 he has been the host of the quiz show QI.