Father

A father is the male parent of a child. Besides the paternal bonds of a father to his children, the father has a parental social and legal relationship with the child that carries with it certain rights and obligations, although this varies between jurisdictions. An adoptive father is a male who has become the child's parent through the legal process of adoption. A biological father is the male genetic contributor to the creation of the baby, through sexual intercourse or sperm donation. A biological father may have legal obligations to a child not raised by him, such as an obligation of monetary support. A putative father is a man whose biological relationship to a child is alleged but has not been established. A stepfather is a male who is the husband of a child's mother and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child.

The adjective "paternal" refers to a father and comparatively to "maternal" for a mother. The verb "to father" means to procreate or to sire a child from which also derives the noun "fathering". Biological fathers determine the sex of their child through a sperm cell which either contains an X chromosome (female), or Y chromosome (male). Related terms of endearment are dad (dada, daddy), papa/pappa, papasita, (pa, pap) and pop. A male role-model that children can look up to is sometimes referred to as a father-figure.

Dad (film)

Dad is a 1989 American comedy-drama film written and directed by Gary David Goldberg and starring Jack Lemmon, Ted Danson, Olympia Dukakis, Kevin Spacey and Ethan Hawke. It is based on William Wharton's novel of the same name. The original music score was composed by James Horner. The film was produced by Amblin Entertainment and distributed by Universal Pictures.

Plot

John Tremont (Ted Danson) is a busy executive. He learns during a meeting that his mother has collapsed and been rushed to the hospital. Flying immediately to Los Angeles, he ends up becoming a caretaker of his father Jake (Jack Lemmon) while Bette Tremont (Olympia Dukakis) recovers from her heart-attack. A retired aerospace industry worker, Jake has become somewhat feeble and totally reliant on his wife, so John attempts to get him more involved in day-to-day things like taking care of the house.

Father and son bond. John invites his dad to a business meeting and takes him out for a Bingo game. They play catch with a baseball in the yard. Late one night, college-aged grandson Billy (Ethan Hawke) turns up as well. John begins to appreciate while spending quality time with his dad that he has been neglecting his own boy.

DAD1

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an enzyme that in humans is encoded by the DAD1 gene.

Function

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.

Interactions

DAD1 has been shown to interact with MCL1.

References

Further reading

Shirley (film)

Shirley is a 1922 British silent drama film directed by A.V. Bramble and starring Carlotta Breese, Clive Brook, Elizabeth Irving and Mabel Terry-Lewis. It is based on the 1849 novel Shirley by Charlotte Brontë.

Cast

References

External links

Shirley (Dutch singer)

Shirley Zwerus, stage name Shirley (Zandvoort, 22 May 1946) is a Dutch singer and pianist. Her records were released internationally on Fontana Records from 1969.

Discography

Albums

Shirley (novel)

Shirley is an 1849 social novel by the English novelist Charlotte Brontë. It was Brontë's second published novel after Jane Eyre (originally published under Brontë's pseudonym Currer Bell). The novel is set in Yorkshire in the period 1811–12, during the industrial depression resulting from the Napoleonic Wars and the War of 1812. The novel is set against a backdrop of the Luddite uprisings in the Yorkshire textile industry.

The novel's popularity led to Shirley's becoming a woman's name. The title character was given the name that her father had intended to give a son. Before the publication of the novel, Shirley was an uncommon - but distinctly male - name and would have been an unusual name for a woman. Today it is regarded as a distinctly female name and an uncommon male name.

Background

While Brontë was writing Shirley, three of her siblings died. Her brother Branwell died in September 1848, and her sister Emily fell ill and died in December. Brontë resumed writing, but then her only remaining sibling, her sister Anne, became ill and died in May 1849.

Wanted (2008 film)

Wanted is a 2008 American-German action thriller film based on the comic book miniseries of the same name by Mark Millar and J. G. Jones. The film, written by Chris Morgan, Michael Brandt, and Derek Haas and directed by Timur Bekmambetov stars James McAvoy, Morgan Freeman, and Angelina Jolie. The storyline follows Wesley Gibson (McAvoy), a frustrated account manager who discovers that he is the son of a professional assassin and decides to join the Fraternity, a secret society in which his father worked.

Universal Studios acquired the adaptation rights from Millar in 2004, and while the eventual script drifted from the comic book supervillain mythos in the original miniseries, Millar was content to see most of the comic's darker content was retained. Production began in April 2007, with filming in the Czech Republic, Budapest, and the story's main setting, Chicago. Wanted was released on June 2008 to both critical and commercial success, with box office earnings of $341 million worldwide and reviews praising the fast pacing and stylized action scenes. A sequel was planned the same year as the film's release, but ultimately stalled in the development phase.