The Holocene extinction refers to the extinction of species during the present Holocene epoch (since around 10,000 BC). The large number of extinctions span numerous families of plants and animals including mammals, birds, amphibians, reptiles and arthropods. Although 875 extinctions occurring between 1500 and 2009 have been documented by the International Union for Conservation of Nature and Natural Resources, the vast majority are undocumented. According to the species-area theory and based on upper-bound estimating, up to 140,000 species per year may be the present rate of extinction.

The Holocene extinction includes the disappearance of large mammals known as megafauna, starting between 9,000 and 13,000 years ago, the end of the last Ice Age. Such disappearances are considered to be results of climate change or the proliferation of modern humans, or both. These extinctions, occurring near the Pleistocene–Holocene boundary, are sometimes referred to as the Quaternary extinction event or Ice Age extinction. The Holocene extinction continues into the 21st century.