Quinestrol

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Quinestrol
Quinestrol.png
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
ATC code none
Identifiers
Systematic (IUPAC) name: (17β)-3-(cyclopentyloxy)-17-ethynylestra-1,3,5(10)-trien-17-ol
Synonyms W-3566;
3-Cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
CAS Number 152-43-2 YesY
PubChem (CID) 9046
IUPHAR/BPS 7097
DrugBank DB04575 YesY
ChemSpider 8694 YesY
UNII JR0N7XD5GZ YesY
KEGG D00576 YesY
ChEBI CHEBI:8716 YesY
ChEMBL CHEMBL1201165 N
Chemical and physical data
Formula C25H32O2
Molar mass 364.52 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Quinestrol (INN, USAN, BAN) (brand names Agalacto-Quilea, Basaquines, Eston, Estrovis, Estrovister, Plestrovis, Qui-Lea), also known as ethinyl estradiol 3-cyclopentyl ether (EE2CPE), is a synthetic, steroidal estrogen used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer.[1][2][3][4] It is a prodrug of ethinyl estradiol (with cyclopentanol also being formed) with no intrinsic estrogenic activity of its own, and has a very long terminal half-life of more than 120 hours due to enhanced lipophilicity.[5] Because of its much longer terminal half-life, quinestrol is two to three times as potent as ethinyl estradiol.[6] The drug was marketed as Estrovis in the United States by Parke Davis and as Qui-Lea in Argentina,[4] but is reportedly not currently marketed.[6] However, it does appear to be available as an oral contraceptive in combination with progestins in Argentina and China.[7] Quinestrol was described in the literature in 1967.[1]

See also[edit]

References[edit]

  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 522–. ISBN 978-1-4757-2085-3. 
  2. ^ I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 243–. ISBN 978-94-011-4439-1. 
  3. ^ Christoph Zink (1 January 1988). Dictionary of Obstetrics and Gynecology. Walter de Gruyter. pp. 204–. ISBN 978-3-11-085727-6. 
  4. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 905–. ISBN 978-3-88763-075-1. 
  5. ^ Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 248–. ISBN 978-3-642-60107-1. 
  6. ^ a b A. Wayne Meikle (1 June 1999). Hormone Replacement Therapy. Springer Science & Business Media. pp. 381–. ISBN 978-1-59259-700-0. 
  7. ^ https://www.drugs.com/international/quinestrol.html



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