November 3

November 3 is the 307th day of the year (308th in leap years) in the Gregorian calendar. There are 58 days remaining until the end of the year.

Events

CLE

CLE may refer to:

Lower East Pubnico (La Field) Airport

Lower East Pubnico (La Field) Airport (TC LID: CLE4) is located 1 nautical mile (1.9 km; 1.2 mi) northeast of Lower East Pubnico, Nova Scotia, Canada.

References

Clef

A clef (from French: clef "key") is a musical symbol used to indicate the pitch of written notes. Placed on one of the lines at the beginning of the stave, it indicates the name and pitch of the notes on that line. This line serves as a reference point by which the names of the notes on any other line or space of the stave may be determined. Only one clef that references a note in a space rather than on a line has ever been used.

There are three types of clef used in modern music notation: F, C, and G. Each type of clef assigns a different reference note to the line (and in rare cases, the space) on which it is placed.

Once one of these clefs has been placed on one of the lines of the stave, the other lines and spaces can be read in relation to it.

The use of three different clefs makes it possible to write music for all instruments and voices, even though they may have very different tessituras (that is, even though some sound much higher or lower than others). This would be difficult to do with only one clef, since the modern stave has only five lines, and the number of pitches that can be represented on the stave, even with ledger lines, is not nearly equal to the number of notes the orchestra can produce. The use of different clefs for various instruments and voices allows each part to be written comfortably on the stave with a minimum of ledger lines. To this end, the G-clef is used for high parts, the C-clef for middle parts, and the F-clef for low parts—with the notable exception of transposing parts, which are written at a different pitch than they sound, often even in a different octave.

Canadian Health Network

The Canadian Health Network (CHN) was established in 1999 as a national, bilingual health promotion service operated by the Public Health Agency of Canada and major health organizations across Canada. It was an on-line collaborative service and includes health information providers such as national and provincial/territorial non-profit organizations, as well as universities, hospitals, libraries and community organizations.

The CHN offered dependable, up-to-date information on health promotion and disease and injury prevention, to help individuals and communities make healthy choices that improve the quality of their life. It was known to be of the most comprehensive networks of its kind in the world. It was a called a 'network' since the information was amalgamated from a variety of Canadian health organizations.

In November 2007, the Public Health Agency of Canada announced that the service would end, and on April 1, 2008, the website was replaced with a redirect notice.

Chimerin 2

Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

Further reading

Chimerin 1

Chimerin 1, (CHN1) also known as alpha-1-chimerin, n-chimerin is a protein which in humans is encoded by the CHN1 gene.

Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may be involved in signal transduction.

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding.

Function

CHN1 is a three-domain protein with the N-terminal SH2 domain, the C-terminal RhoGAP domain and the central C1 domain similar to protein kinase C. When lipid diacylglycerol (DAG) binds to the C1 domain, CHN1 is transferred to the plasma membrane and negatively regulates Rho-family small GTPases RAC1 and CDC42, thus causing the morphological change of axons by pruning the ends of axon dendrites.

Mutational analysis suggests that un-overlapping residues of the RhoGAP domain are involved in RAC1-binding and the RAC1-GAP activity. Regulation of the RhoGAP activity of CHN1 by phorbol esters, natural compounds mimic of the lipid second messenger DAG, presents a possible way of designing agents for therapeutics.