HRG

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Histidine-rich glycoprotein

Histidine-rich glycoprotein (HRG)is a glycoprotein that in humans is encoded by the HRG gene. It possesses a multi-domain structure which makes it capable of binding to numerous ligands, modulating various biological processes including immunity, vascularization and coagulation.

Function

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

HRG is thought to have multiple roles as a protein in the human blood, including roles in immunity, angiogenesis and coagulation.

Hogg Robinson Group

Hogg Robinson Group is an international corporate services organisation with headquarters in the UK. Their brands include HRG, a global travel management company operating in 120 countries, and Spendvision, a software company that specialises in expense management and advanced payment technology. Hogg Robinson Group wholly acquired Spendvision in 2012, before rebranding it as Fraedom in 2015.

Hogg Robinson Group was founded in 1845 by brothers-in-law Francis Hogg, a young wine merchant, and Augustus Robinson, an insurance broker. The partnership developed mercantile and insurance interests from offices in Birchin Lane in the City of London.

The company is traded on the London Stock Exchange under the ticker symbol HRG.L.

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