Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction

Edit PNAS 29 Apr 2015
The tumor suppressor protein Suppressor of fused (Sufu) plays a conserved role in the Hedgehog (Hh) signaling pathway by inhibiting Cubitus interruptus (Ci)/Glioma-associated oncogene homolog (Gli) transcription factors, but the molecular ......

Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator

Edit PNAS 11 Dec 2014
Abstract. Hedgehog (Hh) signaling governs many developmental processes by regulating the balance between the repressor (CiR/GliR) and activator (CiA/GliA) forms of Cubitus interruptus (Ci)/glioma-associated oncogene homolog (Gli) transcription factors ... ....

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila

Edit PNAS 23 Oct 2014
Abstract ... Moreover, aPKC has an additional positive role in Hh signaling by regulating the activity of Cubitus interruptus (Ci) through phosphorylation of the Zn finger DNA-binding domain ... ....
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