ZNF259

ZPR1
Identifiers
Aliases	ZPR1, ZNF259, ZPR1 zinc finger
External IDs	MGI: 1330262 HomoloGene: 2900 GeneCards: ZPR1
Gene ontology Molecular function • receptor tyrosine kinase binding • zinc ion binding • metal ion binding • protein binding • translation initiation factor binding Cellular component • cytoplasm • perikaryon • Cajal body • cell projection • growth cone • nucleoplasm • SMN complex • axon • neuronal cell body • nucleolus • perinuclear region of cytoplasm • nucleus • Gemini of coiled bodies Biological process • cell differentiation • axon development • pre-mRNA catabolic process • Cajal body organization • mRNA processing • apoptotic process involved in development • positive regulation of growth • inner cell mass cell proliferation • cellular response to epidermal growth factor stimulus • positive regulation of gene expression • regulation of myelination • positive regulation of transcription involved in G1/S transition of mitotic cell cycle • RNA splicing • spinal cord development • positive regulation of RNA splicing • positive regulation of protein import into nucleus • cell proliferation • DNA endoreduplication • microtubule cytoskeleton organization • trophectodermal cell proliferation • signal transduction • negative regulation of motor neuron apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8882	22687
Ensembl	ENSG00000109917	ENSMUSG00000032078
UniProt	O75312	Q62384
RefSeq (mRNA)	NM_003904 NM_001317086	NM_011752
RefSeq (protein)	NP_001304015 NP_003895	NP_035882.1
Location (UCSC)	Chr 11: 116.77 – 116.79 Mb	Chr 9: 46.27 – 46.28 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Zinc finger protein ZPR1 is a protein that in humans is encoded by the ZNF259 gene.

Further reading

• Gangwani L, Mikrut M, Galcheva-Gargova Z, Davis RJ (1999). "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.". J. Cell Biol. 143 (6): 1471–84. doi:10.1083/jcb.143.6.1471. PMC 2132977. PMID 9852145. 
• Moores SL, Selfors LM, Fredericks J, et al. (2000). "Vav family proteins couple to diverse cell surface receptors.". Mol. Cell. Biol. 20 (17): 6364–73. doi:10.1128/MCB.20.17.6364-6373.2000. PMC 86111. PMID 10938113. 
• Narayanan U, Ospina JK, Frey MR, et al. (2003). "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.". Hum. Mol. Genet. 11 (15): 1785–95. doi:10.1093/hmg/11.15.1785. PMC 1630493. PMID 12095920. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Gangwani L, Flavell RA, Davis RJ (2005). "ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.". Mol. Cell. Biol. 25 (7): 2744–56. doi:10.1128/MCB.25.7.2744-2756.2005. PMC 1061650. PMID 15767679. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267. 
• Gangwani L (2007). "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression.". J. Biol. Chem. 281 (52): 40330–40. doi:10.1074/jbc.M608165200. PMID 17068332. 

External links

• ZNF259 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.