TAL1

TAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1
External IDs	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • histone deacetylase binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • E-box binding • protein binding • protein heterodimerization activity • enzyme binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • histone deacetylase complex • transcription factor complex • protein complex • nuclear chromatin • Lsd1/2 complex • nucleus Biological process • megakaryocyte development • megakaryocyte differentiation • myeloid cell differentiation • hemopoiesis • cell fate commitment • cell differentiation • regulation of transcription, DNA-templated • regulation of mast cell differentiation • spinal cord association neuron differentiation • positive regulation of protein complex assembly • locomotory behavior • positive regulation of erythrocyte differentiation • regulation of transcription from RNA polymerase II promoter • regulation of stem cell population maintenance • platelet formation • positive regulation of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • generation of neurons • basophil differentiation • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of cell proliferation • hematopoietic stem cell differentiation • astrocyte fate commitment • angiogenesis • neuron differentiation • embryonic hemopoiesis • positive regulation of chromatin assembly or disassembly • erythrocyte differentiation • definitive hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell division • hemangioblast cell differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte maturation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6886	21349
Ensembl	ENSG00000162367	ENSMUSG00000028717
UniProt	P17542	P22091
RefSeq (mRNA)	NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189	NM_011527 NM_001287388
RefSeq (protein)	NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180	NP_001274317.1 NP_035657.1 NP_001274317 NP_035657
Location (UCSC)	Chr 1: 47.22 – 47.23 Mb	Chr 4: 115.06 – 115.07 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

• CBFA2T3,
• EP300,
• GATA1,
• LDB1,
• LMO1,
• LMO2,
• SIN3A,
• Sp1 transcription factor, and
• TCF3.

Further reading

• Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors.". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013. 
• Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.". Blood. 79 (5): 1327–33. PMID 1311214. 
• Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation.". EMBO J. 11 (11): 4073–81. PMC 556917. PMID 1396592. 
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood. 80 (11): 2858–66. PMID 1450410. 
• Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.". Oncogene. 6 (8): 1477–88. PMID 1886719. 
• Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.". Genes Chromosomes Cancer. 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581. 
• Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650. 
• Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus.". Mol. Cell. Biol. 10 (12): 6426–35. PMC 362919. PMID 2247063. 
• Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". EMBO J. 9 (2): 415–24. PMC 551682. PMID 2303035. 
• Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361. 
• Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177. 
• Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues.". Blood. 85 (3): 675–84. PMID 7833471. 
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052. 
• Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932. 
• Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.". Oncogene. 9 (10): 3013–6. PMID 8084606. 
• Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721. 
• Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.". Oncogene. 8 (11): 3043–6. PMID 8414504. 
• Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.". Mol. Cell. Biol. 13 (2): 801–8. PMC 358963. PMID 8423803. 

External links

• TAL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook TAL1