MEIS2

MEIS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K2A, 5BNG, 4XRM
Identifiers
Aliases	MEIS2, HsT18361, MRG1, Meis homeobox 2
External IDs	MGI: 108564 HomoloGene: 7846 GeneCards: MEIS2
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • transcription cofactor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding Cellular component • cytoplasm • perinuclear region of cytoplasm • nucleus Biological process • eye development • visual learning • regulation of transcription, DNA-templated • response to mechanical stimulus • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • multicellular organism development • pancreas development • response to growth factor • negative regulation of myeloid cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4212	17536
Ensembl	ENSG00000134138	ENSMUSG00000027210
UniProt	O14770	P97367
RefSeq (mRNA)	NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316	NM_001136072 NM_001159567 NM_001159568 NM_001159569 NM_001159570 NM_010825
RefSeq (protein)	NP_001207411 NP_002390 NP_733774 NP_733775 NP_733776 NP_733777 NP_758526 NP_758527	NP_001129544.1 NP_001153039.1 NP_001153040.1 NP_001153041.1 NP_034955.1
Location (UCSC)	Chr 15: 36.89 – 37.1 Mb	Chr 2: 115.86 – 116.07 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Further reading

• Hui H, Perfetti R (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.". Eur. J. Endocrinol. 146 (2): 129–41. doi:10.1530/eje.0.1460129. PMID 11834421. 
• Steelman S, Moskow JJ, Muzynski K, et al. (1997). "Identification of a conserved family of Meis1-related homeobox genes.". Genome Res. 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632. 
• Capdevila J, Tsukui T, Rodríquez Esteban C, et al. (2000). "Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin.". Mol. Cell. 4 (5): 839–49. doi:10.1016/S1097-2765(00)80393-7. PMID 10619030. 
• Yang Y, Hwang CK, D'Souza UM, et al. (2000). "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.". J. Biol. Chem. 275 (27): 20734–41. doi:10.1074/jbc.M908382199. PMID 10764806. 
• Liu Y, MacDonald RJ, Swift GH (2001). "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex.". J. Biol. Chem. 276 (21): 17985–93. doi:10.1074/jbc.M100678200. PMID 11279116. 
• Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Dintilhac A, Bihan R, Guerrier D, et al. (2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.". Gene Expr. Patterns. 4 (2): 215–22. doi:10.1016/j.modgep.2003.08.006. PMID 15161102. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 

External links

• MEIS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.