FOXD4

FOXD4
Identifiers
Aliases	FOXD4, FKHL9, FOXD4A, FREAC-5, FREAC5, forkhead box D4
External IDs	MGI: 1347467 HomoloGene: 83248 GeneCards: FOXD4
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • sequence-specific DNA binding; • DNA binding; • DNA binding, bending;
Cellular component	• nucleus;
Biological process	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	2298
	14237
	ENSG00000170122
	ENSMUSG00000051490
	Q12950
	Q60688
	NM_207305
	NM_008022
	NP_997188
	NP_032048.1
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein D4 is a protein that in humans is encoded by the FOXD4 gene.^[3]^[4]^[5]^[6]

References[edit]

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P (Dec 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. PMC 395442. PMID 7957066.
^ Larsson C, Hellqvist M, Pierrou S, White I, Enerback S, Carlsson P (Feb 1997). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
^ Freyaldenhoven BS, Fried C, Wielckens K (Sep 2002). "FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines". Gene. 294 (1-2): 131–140. doi:10.1016/S0378-1119(02)00702-3. PMID 12234674.
^ "Entrez Gene: FOXD4 forkhead box D4".

Cederberg A, Betz R, Lagercrantz S, et al. (1997). "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene.". Genomics. 44 (3): 344–6. doi:10.1006/geno.1997.4864. PMID 9325056.
Fan Y, Newman T, Linardopoulou E, Trask BJ (2003). "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.". Genome Res. 12 (11): 1663–72. doi:10.1101/gr.338402. PMC 187549. PMID 12421752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Minoretti P, Arra M, Emanuele E, et al. (2007). "A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality.". Int. J. Mol. Med. 19 (3): 369–72. doi:10.3892/ijmm.19.3.369. PMID 17273782.

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