FOSL2

FOSL2
Identifiers
Aliases	FOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 trancription factor subunit, FOS like 2, AP-1 transcription factor subunit
External IDs	MGI: 102858 HomoloGene: 3845 GeneCards: FOSL2
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • protein binding • RNA polymerase II regulatory region sequence-specific DNA binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • keratinocyte development • cell death • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of fibroblast proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2355	14284
Ensembl	ENSG00000075426	ENSMUSG00000029135
UniProt	P15408	P47930
RefSeq (mRNA)	NM_005253	NM_008037
RefSeq (protein)	NP_005244.1	NP_032063.2
Location (UCSC)	Chr 2: 28.39 – 28.42 Mb	Chr 5: 32.14 – 32.16 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

See also

• AP-1 (transcription factor)

Further reading

• Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.". Oncogene. 5 (3): 249–55. PMID 2107490. 
• Molven A, Houge G, Berger R (1997). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23.". Genomics. 38 (1): 72–5. doi:10.1006/geno.1996.0593. PMID 8954781. 
• Outinen PA, Sood SK, Pfeifer SI, et al. (1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.". Blood. 94 (3): 959–67. PMID 10419887. 
• Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367. 
• Ng DC, Shafaee S, Lee D, Bikle DD (2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter.". J. Biol. Chem. 275 (31): 24080–8. doi:10.1074/jbc.M002508200. PMID 10816578. 
• Bamberger AM, Milde-Langosch K, Rössing E, et al. (2001). "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators.". J. Cancer Res. Clin. Oncol. 127 (9): 545–50. doi:10.1007/s004320100255. PMID 11570575. 
• Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771. 
• Benkoussa M, Brand C, Delmotte MH, et al. (2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.". Mol. Cell. Biol. 22 (13): 4522–34. doi:10.1128/MCB.22.13.4522-4534.2002. PMC 133906. PMID 12052862. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Santalucía T, Christmann M, Yacoub MH, Brand NJ (2004). "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1.". Cardiovasc. Res. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

External links

• FOSL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook FOSL2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.