TAAR5
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| TAAR5 | |||||||||||||||||
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| Aliases | TAAR5, PNR, trace amine associated receptor 5 | ||||||||||||||||
| External IDs | MGI: 2685073 HomoloGene: 20850 GeneCards: TAAR5 | ||||||||||||||||
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| Location (UCSC) | Chr 6: 132.59 – 132.59 Mb | Chr 10: 23.97 – 23.97 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Trace amine-associated receptor 5 is a protein that in humans is encoded by the TAAR5 gene.[3][4][5] In vertebrates, TAAR5 is expressed in the olfactory epithelium.[6]
Human TAAR5 (hTAAR5) is a functional trace amine-associated receptor which acts as an olfactory receptor for tertiary amines.[6][7] Trimethylamine and N,N-dimethylethylamine are full agonists of hTAAR5.[7][8][9] The amber-woody fragrance timberol antagonizes this activity of trimethylamine.[10] 3-Iodothyronamine is an inverse agonist of hTAAR5.[11][12]
See also[edit]
References[edit]
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Zeng Z, Fan P, Rand E, Kyaw H, Su K, Madike V, Carter KC, Li Y (Mar 1998). "Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain". Biochem Biophys Res Commun. 242 (3): 575–8. doi:10.1006/bbrc.1997.7591. PMID 9464258.
- ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ^ "Entrez Gene: TAAR5 trace amine associated receptor 5".
- ^ a b Liberles SD (2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Curr. Opin. Neurobiol. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMID 25616211.
All TAARs except TAAR1 function as olfactory receptors, based on studies in rodent, primate, and fish [4,7,10]. TAAR expression is highly enriched in the olfactory system by quantitative PCR (qPCR) analysis, with little or no expression in other tissues examined [4].
- ^ a b Zhang LS, Davies SS (April 2016). "Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions". Genome Med. 8 (1): 46. doi:10.1186/s13073-016-0296-x. PMC 4840492
. PMID 27102537.
Table 2: Microbial metabolites: their synthesis, mechanisms of action, and effects on health and disease
Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease - ^ Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G (2013). "Human trace amine-associated receptor TAAR5 can be activated by trimethylamine". PLoS ONE. 8 (2): e54950. doi:10.1371/journal.pone.0054950. PMC 3564852. PMID 23393561.
- ^ Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T (February 2013). "Ultrasensitive detection of amines by a trace amine-associated receptor". J. Neurosci. 33 (7): 3228–39. doi:10.1523/JNEUROSCI.4299-12.2013. PMC 3711460. PMID 23407976.
We show that [human TAAR5] responds to the tertiary amine N,N-dimethylethylamine and to a lesser extent to trimethylamine, a structurally related agonist for mouse and rat TAAR5 (Liberles and Buck, 2006; Staubert et al., 2010; Ferrero et al., 2012).
- ^ Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G (2015). "Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans". PLoS ONE. 10 (12): e0144704. doi:10.1371/journal.pone.0144704. PMC 4684214. PMID 26684881.
- ^ Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H (2015). "Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5". PLoS ONE. 10 (2): e0117774. doi:10.1371/journal.pone.0117774. PMC 4382497. PMID 25706283.
- ^ Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.
Further reading[edit]
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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