3,4-Dihydroxyphenylacetaldehyde
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(Redirected from DOPAL)
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| Names | |
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| Systematic IUPAC name
2-(3,4-Dihydroxyphenyl)acetaldehyde[1]
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| Other names
Dopaldehyde
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| Identifiers | |
5707-55-1  |
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| 3D model (Jmol) | Interactive image Interactive image |
| 3DMet | B00668 |
| Abbreviations | DOPAL |
| ChEBI | CHEBI:27978  |
| ChemSpider | 106504 |
| ECHA InfoCard | 100.237.172 |
| 6632 | |
| KEGG | C04043 |
| MeSH | 3,4-dihydroxyphenylacetaldehyde |
| PubChem | 119219 |
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| Properties | |
| C8H8O3 | |
| Molar mass | 152.15 g·mol−1 |
| Density | 1.306 g/mL |
| Boiling point | 351 °C (664 °F; 624 K) |
| Related compounds | |
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Related 2-phenyl aldehydes
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Phenylacetaldehyde |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 verify (what is ?) |
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| Infobox references | |
3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a metabolite of the neurotransmitter dopamine. DOPAL is an important precursor of the major brain metabolites of dopamine, 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxy-phenylacetic acid. DOPAL plays a role in Parkinson's disease.[2] DOPAL has been chemically synthesized.[3]
References[edit]
- ^ "3,4-dihydroxyphenylacetaldehyde - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. Identification and Related Records. Retrieved 13 October 2011.
- ^ Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ, Sharabi Y., "Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease," J Neurochem. 2013 Sep;126(5):591-603.
- ^ Li, W., Spaziano, V.T., Burke, WJ., "Synthesis of a biochemicallly important aldehyde - 3,4-dihydroxyphenylacetaldehyde", Bio-Organic Chemistry, 26, 45-50, 1998.
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