Bradykinin receptor B2

BDKRB2
Identifiers
Aliases	BDKRB2, B2R, BK-2, BK2, BKR2, BRB2, bradykinin receptor B2
External IDs	MGI: 102845 HomoloGene: 519 GeneCards: BDKRB2
Targeted by Drug
Bradykinin, kallidin
Gene ontology Molecular function • G-protein coupled receptor activity • type 1 angiotensin receptor binding • signal transducer activity • protease binding • protein binding • protein heterodimerization activity • phosphatidylinositol phospholipase C activity • bradykinin receptor activity Cellular component • integral component of membrane • endosome • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to salt stress • vasoconstriction • transmembrane receptor protein tyrosine kinase signaling pathway • response to stress • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • vasodilation • blood circulation • cell surface receptor signaling pathway • regulation of vascular permeability • regulation of vasoconstriction • negative regulation of peptidyl-serine phosphorylation • inflammatory response • arachidonic acid secretion • signal transduction • smooth muscle contraction • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	624	12062
Ensembl	ENSG00000168398	ENSMUSG00000021070
UniProt	P30411	P32299
RefSeq (mRNA)	NM_000623	NM_009747
RefSeq (protein)	NP_000614	NP_033877.3 NP_033877
Location (UCSC)	Chr 14: 96.2 – 96.24 Mb	Chr 12: 105.56 – 105.59 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Bradykinin receptor B₂ is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

Mechanism

The B₂ receptor is a G protein-coupled receptor, probably coupled to G_q and G_i. G_q stimulates phospholipase C to increase intracellular free calcium and G_i inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B₂ receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B₂ receptors.

Kallidin also signals through the B₂ receptor. An antagonist for the receptor is Hoe 140 (icatibant).

Function

The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.

Gene

Alternate start codons result in two isoforms of the protein.

See also

• Bradykinin receptor

External links

• "Bradykinin Receptors: B₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Human BDKRB2 genome location and BDKRB2 gene details page in the UCSC Genome Browser.

Further reading

• Duchêne J, Schanstra J, Cellier E, et al. (2002). "[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway]". Néphrologie. 23 (1): 39–41. PMID 11908480. 
• Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
• Hess JF, Borkowski JA, Young GS, et al. (1992). "Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.". Biochem. Biophys. Res. Commun. 184 (1): 260–8. doi:10.1016/0006-291X(92)91187-U. PMID 1314587. 
• Eggerickx D, Raspe E, Bertrand D, et al. (1992). "Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.". Biochem. Biophys. Res. Commun. 187 (3): 1306–13. doi:10.1016/0006-291X(92)90445-Q. PMID 1329734. 
• Kammerer S, Braun A, Arnold N, Roscher AA (1995). "The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region.". Biochem. Biophys. Res. Commun. 211 (1): 226–33. doi:10.1006/bbrc.1995.1800. PMID 7779089. 
• Braun A, Kammerer S, Böhme E, et al. (1995). "Identification of polymorphic sites of the human bradykinin B2 receptor gene.". Biochem. Biophys. Res. Commun. 211 (1): 234–40. doi:10.1006/bbrc.1995.1801. PMID 7779090. 
• Ma JX, Wang DZ, Ward DC, et al. (1995). "Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.". Genomics. 23 (2): 362–9. doi:10.1006/geno.1994.1512. PMID 7835885. 
• Powell SJ, Slynn G, Thomas C, et al. (1993). "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14.". Genomics. 15 (2): 435–8. doi:10.1006/geno.1993.1084. PMID 7916737. 
• Menke JG, Borkowski JA, Bierilo KK, et al. (1994). "Expression cloning of a human B1 bradykinin receptor.". J. Biol. Chem. 269 (34): 21583–6. PMID 8063797. 
• Hess JF, Borkowski JA, Macneil T, et al. (1994). "Differential pharmacology of cloned human and mouse B2 bradykinin receptors.". Mol. Pharmacol. 45 (1): 1–8. PMID 8302267. 
• McIntyre P, Phillips E, Skidmore E, et al. (1993). "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity.". Mol. Pharmacol. 44 (2): 346–55. PMID 8394991. 
• AbdAlla S, Godovac-Zimmermann J, Braun A, et al. (1996). "Structure of the bradykinin B2 receptors' amino terminus.". Biochemistry. 35 (23): 7514–9. doi:10.1021/bi9601060. PMID 8652530. 
• Isami S, Kishikawa H, Araki E, et al. (1996). "Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway.". Diabetologia. 39 (4): 412–20. doi:10.1007/BF00400672. PMID 8777990. 
• Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL (1996). "Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms.". Eur. J. Cell Biol. 69 (3): 236–44. PMID 8900488. 
• Soskic V, Nyakatura E, Roos M, et al. (1999). "Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells.". J. Biol. Chem. 274 (13): 8539–45. doi:10.1074/jbc.274.13.8539. PMID 10085087. 
• Cassano G, Susca F, Lippe C, Guanti G (1999). "Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts.". Gen. Pharmacol. 32 (2): 239–44. doi:10.1016/S0306-3623(98)00275-4. PMID 10188626. 
• Efremov R, Truong MJ, Darcissac EC, et al. (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function.". Eur. J. Biochem. 263 (3): 746–56. doi:10.1046/j.1432-1327.1999.00553.x. PMID 10469138. 
• Marrero MB, Venema VJ, Ju H, et al. (1999). "Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.". Biochem. J. 343 (2): 335–40. doi:10.1042/0264-6021:3430335. PMC 1220558. PMID 10510297. 
• Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L (2000). "Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases". J. Cell. Biochem. 76 (4): 658–73. doi:10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7. PMID 10653985. 
• Golser R, Gorren AC, Leber A, et al. (2000). "Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation". J. Biol. Chem. 275 (8): 5291–6. doi:10.1074/jbc.275.8.5291. PMID 10681501. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.