Ro 04-6790

Ro 04-6790
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide;
CAS Number	202466-68-0;
PubChem CID	5312145;
IUPHAR/BPS	274;
ChemSpider	4471575;
ChEMBL	CHEMBL433461;
Chemical and physical data
Formula	C12H16N6O2S
Molar mass	308.359 g/mol
3D model (Jmol)	Interactive image;
	SMILES Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1 ;
	InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) ; Key:JELFWSXQTXRMAJ-UHFFFAOYSA-N ;
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Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT₆ serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,^[1] Ro 04-6790 has nootropic effects in animals,^[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine^[3] and scopolamine.^[4]

References[edit]

^ Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi:10.1016/j.neuropharm.2008.06.061 PMID 18655798
^ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berlin). 2008 Oct 7. PMID 18839151
^ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
^ Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berlin). 2003 Dec;170(4):358-67. PMID 13680084

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Clinical data

ATC code	none
Identifiers
IUPAC name 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide
CAS Number	202466-68-0
PubChem CID	5312145
IUPHAR/BPS	274
ChemSpider	4471575
ChEMBL	CHEMBL433461
Chemical and physical data
Formula	C₁₂H₁₆N₆O₂S
Molar mass	308.359 g/mol
3D model (Jmol)	Interactive image
SMILES Nc2ccc(cc2)S(=O)(=O)Nc1cc(NC)nc(NC)n1
InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) Key:JELFWSXQTXRMAJ-UHFFFAOYSA-N
(verify)