Mesulergine
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Formula | C18H26N4O2S |
Molar mass | 362.49 g/mol |
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Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors.[1][2]
The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.[3]
See also[edit]
References[edit]
- ^ Closse A (May 1983). "[3H]-Mesulergine, a selective ligand for serotonin-2 receptors". Life Sci. 32 (21): 2485–95. doi:10.1016/0024-3205(83)90375-2. PMID 6855451.
- ^ Markstein R (November 1983). "Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors". Eur. J. Pharmacol. 95 (1-2): 101–7. doi:10.1016/0014-2999(83)90272-8. PMID 6230246.
- ^ Dupont E, Mikkelsen B, Jakobsen J (April 1986). "Mesulergine in early Parkinson's disease: a double blind controlled trial". J. Neurol. Neurosurg. Psychiatr. 49 (4): 390–5. doi:10.1136/jnnp.49.4.390. PMC 1028763
. PMID 3517235.
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Lysergic acid derivatives |
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Psychedelic lysergamides |
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Other ergolines |
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Natural sources |
Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui) |
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