Zolmitriptan
Clinical data
Trade names
Zomig
AHFS /Drugs.com
Monograph
Pregnancy
category
AU : B3
US : C (Risk not ruled out)
Routes of
administration
Oral, nasal spray
ATC code
N02CC03 (WHO )
Legal status
Legal status
Pharmacokinetic data
Bioavailability
40% (oral)
Protein binding
25%
Metabolism
Hepatic (CYP1A2 -mediated, to active metabolite)
Biological half-life
3 hours
Excretion
Renal (65%) and fecal (35%)
Identifiers
(S )-4-({3-[2-(Dimethylamino)ethyl]-1H -indol-5-yl}methyl)-1,3-oxazolidin-2-one
CAS Number
139264-17-8 Y
PubChem (CID)
60857
IUPHAR/BPS
60
DrugBank
DB00315 Y
ChemSpider
54844 Y
UNII
2FS66TH3YW Y
KEGG
D00415 Y
ChEBI
CHEBI:10124 Y
ChEMBL
CHEMBL1185 Y
ECHA InfoCard
100.158.186
Chemical and physical data
Formula
C 16 H 21 N 3 O 2
Molar mass
287.357 g/mol
3D model (Jmol )
Interactive image
O=C1OC[C@@H](N1)Cc2ccc3c(c2)c(c[nH]3)CCN(C)C
InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
Y
Key:ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Y
(verify)
Zolmitriptan is a selective serotonin receptor agonist of the 1B and 1D subtypes. It is a triptan , used in the acute treatment of migraine attacks with or without aura and cluster headaches .
Zolmitriptan is marketed by AstraZeneca with the brand names Zomig , Zomigon (Argentina, Canada & Greece), AscoTop (Germany) and Zomigoro (France). In 2008, Zomig generated nearly $154 million in sales.[1]
AstraZeneca's U.S. patent on Zomig tablets expired on November 14, 2012, and its pediatric exclusivity extension expired on May 14, 2013.[2] The patent in certain European countries has already expired too, and generic drug maker Actavis released a generic version in those countries, starting in March 2012.[3]
Description [ edit ]
Zolmitriptan is a synthetic tryptamine derivative and appears as a white powder that is partially soluble in water.
Indications [ edit ]
Zolmitriptan is used for the acute treatment of migraines with or without aura in adults. Zolmitriptan is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine.
Zolmitriptan is available as a swallowable tablet, an oral disintegrating tablet, and a nasal spray, in doses of 2.5 and 5 mg. People who get migraines from aspartame should not use the disintegrating tablet (Zomig ZMT), which contains aspartame.[4]
According to a study of healthy volunteers, food intake seems to have no significant effect on the effectiveness of Zolmitriptan in both men and women.[5]
Contraindications and precautions [ edit ]
Zolmitriptan should not be given to patients with ischemic heart disease (angina pectoris , history of myocardial infarction , or documented silent ischemia) or to patients who have symptoms or findings consistent with ischemic heart disease, coronary artery vasospasm , including Prinzmetal's angina , or other significant underlying cardiovascular disease.
Zolmitriptan may increase blood pressure , it should not be given to patients with uncontrolled hypertension, should not be used within 24 hours of treatment with another 5-HT1 agonist, or an ergotamine-containing or ergot-type medication like dihydroergotamine or methysergide , and should not be administered to patients with hemiplegic or basilar migraine.
Concurrent administration of MAOI or use of zolmitriptan within 2 weeks of discontinuation of MAO-A inhibitor therapy is contraindicated.
Adverse reactions [ edit ]
The Zomig ZMT dissolvable pill contains aspartame, and should be avoided by anyone sensitive to that ingredient and by those suffering from phenylketonuria .
Rarely, serious cardiac events, including myocardial infarction , have been associated with zolmitriptan.
Reported minor adverse reactions include: hypesthesia , paresthesia (all types), warm and cold sensations, chest pain , throat and jaw tightness, dry mouth, dyspepsia , dysphagia , nausea , somnolence , vertigo , asthenia , myalgia , myasthenia and sweating .
Drug Interactions: see Zomig package insert for complete list: [1]
Following administration of cimetidine, the half-life and AUC of zolmitriptan and its active metabolites were approximately doubled (see CLINICAL PHARMACOLOGY in product pamphlet). Cimetidine (INN) ( or ) is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach.
References [ edit ]
^ "" 2008 Top 200 generic drugs by retail dollars" " (PDF) . [dead link ] (332 KB) . Drug Topics (May 26, 2009). Retrieved on August 25, 2009.
^ http://www.drugs.com/availability/generic-zomig-zmt.html
^ http://www.actavis.com/en/media+center/newsroom/articles/migraine_zolmitriptan_eu.htm
^ Newman LC, Lipton RB (2001). "Migraine MLT-Down: An Unusual Presentation of Migraine in Patients With Aspartame-Triggered Headaches". Headache: the Journal of Head and Face Pain (abstract). 41 (9): 899–901. doi :10.1046/j.1526-4610.2001.01164.x .
^ Emma J. Seaber; Richard W. Peck; Deborah A. Smith; John Allanson; Nanco R. Hefting; Jan J. van Lier; Frans A.E. Sollie; Johan Wemer; Jan H.G. Jonkman (1998). "The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.". British Journal of Clinical Pharmacology (abstract). 46 (5): 433–439. doi :10.1046/j.1365-2125.1998.00809.x .
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