Avitriptan

Avitriptan
Clinical data
ATC code	none;
Legal status
Legal status	Never marketed;
Identifiers
	IUPAC name 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide;
CAS Number	151140-96-4 ;
PubChem CID	133081;
ChemSpider	117442 ;
UNII	6RS056L04P;
KEGG	D03014 ;
ChEMBL	CHEMBL2105880 ;
Chemical and physical data
Formula	C22H30N6O3S
Molar mass	458.58 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=S(=O)(NC)Cc1ccc2c(c1)c(cn2)CCCN4CCN(c3ncncc3OC)CC4 ;
	InChI InChI=1S/C22H30N6O3S/c1-23-32(29,30)15-17-5-6-20-19(12-17)18(13-25-20)4-3-7-27-8-10-28(11-9-27)22-21(31-2)14-24-16-26-22/h5-6,12-14,16,23,25H,3-4,7-11,15H2,1-2H3 ; Key:WRZVGHXUPBWIOO-UHFFFAOYSA-N ;
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Avitriptan (INN) (code name BMS-180,048) is an antimigraine drug of the triptan family which was never marketed.^[1] It acts as a 5-HT_1B and 5-HT_1D receptor agonist.^[1]

References[edit]

^ ^a ^b Saxena PR, De Vries P, Wang W, et al. (February 1997). "Effects of avitriptan, a new 5-HT 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential". Naunyn-Schmiedeberg's Archives of Pharmacology. 355 (2): 295–302. doi:10.1007/pl00004946. PMID 9050026. Archived from the original on 1999-10-23.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[pmid9050026-1] Saxena PR, De Vries P, Wang W, et al. (February 1997). "Effects of avitriptan, a new 5-HT 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential". Naunyn-Schmiedeberg's Archives of Pharmacology. 355 (2): 295–302. doi:10.1007/pl00004946. PMID 9050026. Archived from the original on 1999-10-23.

[1]

v t e Piperazines

Simple piperazines (no additional rings)	1-Cyclohexylpiperazine Aminoethylpiperazine Diethylcarbamazine HEPPS Midafotel Piperazine PIPES

Phenylpiperazines	Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin CSP-2503 Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Naphthylpiperazine Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635

Benzylpiperazines	2C-B-BZP Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide Piberaline Piribedil Sunifiram Trimetazidine Vesnarinone

Diphenylalkylpiperazines (benzhydrylalkylpiperazines)	Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine Lidoflazine Manidipine Meclozine Oxatomide SNC-80 Vanoxerine

Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Prazitone Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone

Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine Pyridinylpiperazine

Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone

Tricyclics (piperazine attached via side chain)	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol

Others/Uncategorized	6-Nitroquipazine Azimilide Cinepazet Cinepazic acid Cinepazide Cyclohexylpiperazine EGIS-7625 Hexocyclium Indinavir JNJ-7777120 Lodenafil Mirodenafil PB-28 Quipazine Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VUF-6002 Zipeprol

Avitriptan

See also[edit]

References[edit]

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Clinical data

ATC code	none
Legal status
Legal status	Never marketed
Identifiers
IUPAC name 1-[3-[3-[4-(5-methoxypyrimidin-4-yl)piperazin-1-yl]propyl]-1H-indol-5-yl]-N-methyl-methanesulfonamide
CAS Number	151140-96-4^N
PubChem CID	133081
ChemSpider	117442^Y
UNII	6RS056L04P
KEGG	D03014^N
ChEMBL	CHEMBL2105880^N
Chemical and physical data
Formula	C₂₂H₃₀N₆O₃S
Molar mass	458.58 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(NC)Cc1ccc2c(c1)c(cn2)CCCN4CCN(c3ncncc3OC)CC4
InChI InChI=1S/C22H30N6O3S/c1-23-32(29,30)15-17-5-6-20-19(12-17)18(13-25-20)4-3-7-27-8-10-28(11-9-27)22-21(31-2)14-24-16-26-22/h5-6,12-14,16,23,25H,3-4,7-11,15H2,1-2H3^Y Key:WRZVGHXUPBWIOO-UHFFFAOYSA-N^Y
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