GPR65

GPR65
Identifiers
Aliases	GPR65, TDAG8, hTDAG8, G protein-coupled receptor 65
External IDs	MGI: 108031 HomoloGene: 2675 GeneCards: GPR65
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • multicellular organism development • actin cytoskeleton reorganization • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • immune response • positive regulation of stress fiber assembly • activation of GTPase activity • response to acidic pH • signal transduction • apoptotic process • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8477	14744
Ensembl	ENSG00000140030	ENSMUSG00000021886
UniProt	Q8IYL9	Q61038
RefSeq (mRNA)	NM_003608	NM_008152
RefSeq (protein)	NP_003599	NP_032178.1 NP_032178
Location (UCSC)	Chr 14: 88.01 – 88.01 Mb	Chr 12: 98.27 – 98.28 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Psychosine receptor is a protein that in humans is encoded by the GPR65 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• Im DS, Heise CE, Nguyen T, et al. (2001). "Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation". J. Cell Biol. 153 (2): 429–34. doi:10.1083/jcb.153.2.429. PMC 2169470. PMID 11309421. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
• Sin WC, Zhang Y, Zhong W, et al. (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene. 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007. 
• Wang JQ, Kon J, Mogi C, et al. (2004). "TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor". J. Biol. Chem. 279 (44): 45626–33. doi:10.1074/jbc.M406966200. PMID 15326175. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Ishii S, Kihara Y, Shimizu T (2005). "Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor". J. Biol. Chem. 280 (10): 9083–7. doi:10.1074/jbc.M407832200. PMID 15618224. 
• Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.