Nuciferine
From Wikipedia, the free encyclopedia
![]() |
|
Names | |
---|---|
IUPAC name
(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
|
|
Other names
(R)-1,2-Dimethoxyaporphine
|
|
Identifiers | |
3D model (Jmol)
|
|
ChemSpider | |
PubChem CID
|
|
|
|
|
|
Properties | |
C19H21NO2 | |
Molar mass | 295.376 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
|
![]() ![]() ![]() |
|
Infobox references | |
Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.[1] It induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy; it inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. Nuciferine may also potentiate morphine analgesia. The median lethal dose in mice is 289 mg/kg. It is structurally related to apomorphine.[2][3]
See also[edit]
References[edit]
- ^ Farrell MS et al. (2016): "In Vitro and In Vivo Characterization of the Alkaloid Nuciferine", PLoS One. PMID 26963248
- ^ Bhattacharya SK, Bose R, Ghosh P, Tripathi VJ, Ray AB, Dasgupta B (Sep 1978). "Psychopharmacological studies on (—)-nuciferine and its Hofmann degradation product atherosperminine". Psychopharmacology (Berl.). 59 (1): 29–33. doi:10.1007/BF00428026. PMID 100809.
- ^ Spess, David L. Errors in Alkaloids of Nelumbo and Nymphaea species, 2011, academia.edu
![]() |
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |