Mepyramine
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
MedlinePlus | a606008 |
ATC code | |
ECHA InfoCard | 100.001.912 |
Identifiers | |
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Synonyms | N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine |
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Chemical and physical data | |
Formula | C17H23N3O |
Molar mass | 285.38 g/mol |
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Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.
Synthesis[edit]
See also[edit]
- Chloropyramine (chloro instead of methoxy)
References[edit]
- ^ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology. 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721
. PMID 16402096.
- ^ Active Ingredients for Midol Complete
- ^ R.J. Horclois, U.S. Patent 2,502,151 (1950).
- ^ Huttrer, C. P.; Djerassi, C.; Beears, W. L.; Mayer, R. L.; Scholz, C. R. (1946). "Heterocyclic amines with antithistaminic activity". Journal of the American Chemical Society. 68 (10): 1999–2002. doi:10.1021/ja01214a037. PMID 21001124.
- ^ D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).
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