Ebalzotan

Ebalzotan
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (3R)-N-(propan-2-yl)-3-[propan-2-yl(propyl)amino]-3,4-dihydro-2H-chromene-5-carboxamide;
CAS Number	149494-37-1;
PubChem CID	9797080;
ChemSpider	7972846;
UNII	WV4B56N49H;
ChEMBL	CHEMBL1742470;
Chemical and physical data
Formula	C19H30N2O2
Molar mass	318.45 g/mol
3D model (Jmol)	Interactive image;
	SMILES O=C(NC(C)C)c2cccc1OC[C@H](N(C(C)C)CCC)Cc12 ;

Ebalzotan (NAE-086) is a selective 5-HT_1A receptor agonist.^[1]^[2] It was under development as an antidepressant and anxiolytic agent but produced undesirable side effects in phase I clinical trials and was subsequently discontinued.^[1]^[2]

References[edit]

v t e Anxiolytics (N05B)

5-HT_1A agonists	Buspirone Tandospirone

GABA_AR PAMs	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam Others: Alpidem^‡ Barbiturates Carbamates Chlormezanone^‡ Ethanol Etifoxine; Herbs: Kava Skullcap Valerian

α₂δ VDCC blockers	Gabapentin Gabapentin enacarbil Phenibut Pregabalin

Antidepressants	SSRIs SNRIs SARIs TCAs TeCAs MAOIs; Others: Agomelatine Bupropion Vilazodone Vortioxetine

Sympatholytics	Beta blockers (e.g., propranolol) Clonidine Dexmedetomidine Guanfacine Prazosin

Others	Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum

Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name (3R)-N-(propan-2-yl)-3-[propan-2-yl(propyl)amino]-3,4-dihydro-2H-chromene-5-carboxamide
CAS Number	149494-37-1
PubChem CID	9797080
ChemSpider	7972846
UNII	WV4B56N49H
ChEMBL	CHEMBL1742470
Chemical and physical data
Formula	C₁₉H₃₀N₂O₂
Molar mass	318.45 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(NC(C)C)c2cccc1OC[C@H](N(C(C)C)CCC)Cc12