JWH-167

JWH-167
Names
	IUPAC name 2-phenyl-1-(1-pentylindol-3-yl)ethanone
	Other names 1-(1-pentyl-1H-indol-3-yl)-2-phenylethanone
Identifiers
CAS Number	864445-37-4 ;
3D model (Jmol)	Interactive image;
ChemSpider	23256084 ;
PubChem CID	44397502;
	InChI InChI=1S/C21H23NO/c1-2-3-9-14-22-16-19(18-12-7-8-13-20(18)22)21(23)15-17-10-5-4-6-11-17/h4-8,10-13,16H,2-3,9,14-15H2,1H3 Key: AMCPOEOUXQWESI-UHFFFAOYSA-N ;
	SMILES CCCCCn1cc(c2c1cccc2)C(=O)Cc3ccccc3 ;
Properties
Chemical formula	C21H23NO
Molar mass	305.42 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

JWH-167 (1-pentyl-3-(phenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75x selectivity for CB₁ with a K_i of 90nM ± 17 and 159nM ± 14 at CB₂. Similar to the related 2'-methoxy compound JWH-250, and the 2'-chloro compound JWH-203, JWH-167 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.^[1]^[2]

References[edit]

^ Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223.
^ Manera C, Tuccinardi T, Martinelli A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in medicinal chemistry. 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.

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