Alprenolol

Alprenolol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C07AA01 (WHO);
Pharmacokinetic data
Protein binding	80% - 90%
Biological half-life	2-3 hours → 4-OH-alprenolol
Identifiers
	IUPAC name (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol;
CAS Number	13655-52-2 ;
PubChem CID	2119;
IUPHAR/BPS	563;
DrugBank	DB00866 ;
ChemSpider	2035 ;
UNII	877K5MQ27W;
KEGG	D07156 ;
ChEBI	CHEBI:51211 ;
ChEMBL	CHEMBL266195 ;
ECHA InfoCard	100.033.750
Chemical and physical data
Formula	C15H23NO2
Molar mass	249.34 g/mol
3D model (Jmol)	Interactive image;
	SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C ;
	InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 ; Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N ;
(verify)

Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as 5-HT_1A receptor antagonist, used in the treatment of angina pectoris.^[1] It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.

References[edit]

^ Hickie JB (August 1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. PMID 4393977.

This article about an amine is a stub. You can help Wikipedia by expanding it.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

v t e Beta blockers (C07)

β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol Sotalol Tertatolol Timolol

β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol S-Atenolol Talinolol

β₂-selective	Butaxamine

α₁- + β-selective	Arotinolol Carvedilol Labetalol

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C07AA01 (WHO)
Pharmacokinetic data
Protein binding	80% - 90%
Biological half-life	2-3 hours → 4-OH-alprenolol
Identifiers
IUPAC name (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
CAS Number	13655-52-2^Y
PubChem CID	2119
IUPHAR/BPS	563
DrugBank	DB00866^Y
ChemSpider	2035^Y
UNII	877K5MQ27W
KEGG	D07156^Y
ChEBI	CHEBI:51211^Y
ChEMBL	CHEMBL266195^Y
ECHA InfoCard	100.033.750
Chemical and physical data
Formula	C₁₅H₂₃NO₂
Molar mass	249.34 g/mol
3D model (Jmol)	Interactive image
SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C
InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3^Y Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N^Y
(verify)