FZD7
Iz Wikipedije, slobodne enciklopedije
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| Uvojiti receptor 7 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | FZD7; FzE3 | ||||||||||
| Vanjski ID | OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8324 | 14369 | |||||||||
| Ensembl | ENSG00000155760 | ENSMUSG00000041075 | |||||||||
| UniProt | O75084 | Q810L8 | |||||||||
| RefSeq (mRNA) | NM_003507.1 | NM_008057.3 | |||||||||
| RefSeq (protein) | NP_003498.1 | NP_032083.3 | |||||||||
| Lokacija (UCSC) | Chr 2: 202.9 - 202.9 Mb |
Chr 1: 59.54 - 59.54 Mb |
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| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.[1][2][3]
Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.[3]
Sadržaj/Садржај
Interakcije[uredi - уреди | uredi izvor]
FZD7 formira interakcije sa DLG4.[4]
Reference[uredi - уреди | uredi izvor]
- ↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
- ↑ 3.0 3.1 "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324.
- ↑ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. (Netherlands) 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714.
Literatura[uredi - уреди | uredi izvor]
- Finch PW, He X, Kelley MJ et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
- Omoto S, Hayashi T, Kitahara K et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vincan E, Darcy PK, Smyth MJ et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Vincan E, Darcy PK, Farrelly CA et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
- Struewing IT, Barnett CD, Zhang W et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.
Vidi još[uredi - уреди | uredi izvor]
Spoljašnje veze[uredi - уреди | uredi izvor]
- "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065.
