Butyrophenone
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| Names | |||
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| IUPAC name
1-phenylbutan-1-one
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| Identifiers | |||
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3D model (Jmol)
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| ChemSpider | |||
| ECHA InfoCard | 100.007.091 | ||
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PubChem CID
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| Properties | |||
| C10H12O | |||
| Molar mass | 148.20 g/mol | ||
| Appearance | colorles liquid | ||
| Melting point | 12 °C (54 °F; 285 K) | ||
| Boiling point | 229 °C (444 °F; 502 K) | ||
| negligible | |||
| log P | 2.77 | ||
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Refractive index (nD)
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1.520 | ||
| Hazards | |||
| NFPA 704 | |||
| Flash point | 99 °C (210 °F; 372 K) | ||
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |||
Butyrophenone is a chemical compound; some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.[1]
Examples of butyrophenones include:
- Haloperidol, the most widely used classical antipsychotic drug in this class[1]
- Benperidol, the most potent commonly used antipsychotic ( 200 times more potent than chlorpromazine)[1][2]
References[edit]
- ^ a b c Keith Parker; Laurence Brunton Goodman; Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th ed.). New York: McGraw-Hill. ISBN 0071422803.
- ^ Grogan, Charles H.; Rice, Leonard M. (1967). "Ω-Azabicyclic Butyrophenones". Journal of Medicinal Chemistry. 10 (4): 621. doi:10.1021/jm00316a022. PMID 6037051.
