Testifenon
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| Synonyms | Testiphenon; Testiphenone; Chlorphenacyl dihydrotestosterone ester; Dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate; LS-19378 |
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| Formula | C31H43Cl2NO3 |
| Molar mass | 548.589 g/mol |
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Testifenon, also known as testiphenon or testiphenone, as well as chlorphenacyl dihydrotestosterone ester or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic-androgenic steroid (AAS) and an alkylating antineoplastic agent (i.e., chemotherapeutic) that was never marketed.[1][2][3] It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body.[1][2] The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.[1][2]
See also[edit]
- Cytestrol acetate (11α-hydroxyethinylestradiol 3-(bis(2-chloroethyl)carbamate) 11α,17β-diacetate)
- LS-1727 (nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate)
References[edit]
- ^ a b c Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM (1988). "[The antineoplastic activity of testiphenon]". Vopr Onkol (in Russian). 34 (11): 1363–8. PMID 3201773.
- ^ a b c Demidova, N. V.; Serebryakova, E. A.; Gasan-Guseinova, Z. G.; Zimakova, N. I.; Arzamastsev, A. P. (1995). "Comparative pharmacokinetics of3H-testiphenone and3H-chlorophenacyl in peroral administration to mice". Pharmaceutical Chemistry Journal. 29 (11): 737–739. doi:10.1007/BF02331848. ISSN 0091-150X.
- ^ Oborotova NA, Smirnova ZS, Polozkova ZS, Baryshnikov AI (2002). "[Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics]". Vestn. Akad. Med. Nauk SSSR (in Russian) (1): 42–5. PMID 11882971.
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