Idoxifene
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Systematic (IUPAC) name: (E)-1-(2-(4-(1-(4-Iodophenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)pyrrolidine
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| CAS Number | 116057-75-1 |
| PubChem (CID) | 3034011 |
| ChemSpider | 2298565 |
| UNII | 456UXE9867  |
| ChEMBL | CHEMBL6318 |
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| Formula | C28H30INO |
| Molar mass | 523.4 g/mol |
| 3D model (Jmol) | Interactive image |
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Idoxifene is a non-steroidal estrogen antagonist.[1] It is structurally analogous to tamoxifen.
A large-scale synthesis has been devised.[2]
References[edit]
- ^ McCague, R; Leclercq, G; Legros, N; Goodman, J; Blackburn, GM; Jarman, M; Foster, AB (1989). "Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent". Journal of Medicinal Chemistry. 32 (12): 2527–33. doi:10.1021/jm00132a006. PMID 2585441.
- ^ McCague, Raymond; Potter, Gerard A.; Jarman, Michael (1994). "AN EFFICIENT, LARGE-SCALE SYNTHESIS OF IDOXIFENE {(E)-1-[4-[2-(N-PYRROLIDINO)ETHOXY]PHENYL]-1-(4-IODOPHENYL)-2-PHENYL-1-BUTENE}". Organic Preparations and Procedures International. 26 (3): 343–346. doi:10.1080/00304949409458432. ISSN 0030-4948.
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