BD1060
From Wikipedia, the free encyclopedia
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CAS Number | 138356-10-2 |
PubChem (CID) | 9882367 |
ChemSpider | 8058042 |
Chemical and physical data | |
Formula | C14H20Cl2N2 |
Molar mass | 287.23 g/mol |
3D model (Jmol) | Interactive image |
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BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.[1]
Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.[1]
See also[edit]
References[edit]
- ^ a b Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.