Akuammine
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| Other names
Vincamajoridine
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| C22H26N2O4 | |
| Molar mass | 382.46 g·mol−1 |
| Melting point | 225 °C (437 °F; 498 K)[1] |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Akuammine (vincamajoridine[2]) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida,[3] commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major.[2] Akuammine is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with pharmacological properties.
Pharmacology[edit]
Akuammine has antimalarial activity,[3] and may be the primary constituent of P. nitida seeds responsible for this activity.[4]
Akuammine is an opioid antagonist with low afinity, selective for the mu-opioid receptor, when tested in vitro.[5][6]
References[edit]
- ^ Merck Index (12th ed.). 200.
- ^ a b Janot, M. M.; Le Men, J.; Aghoramurthy, K.; Robinson, R. (1955). "The identity of vincamajoridine and akuammine". Experientia. 11 (9): 343. doi:10.1007/BF02159911.
- ^ a b Kapadia, G. J.; Angerhofer, C. K.; Ansa-Asamoah, R (1993). "Akuammine: An antimalarial indolemonoterpene alkaloid of Picralima nitida seeds". Planta Medica. 59 (6): 565–6. PMID 8302957. doi:10.1055/s-2006-959764.
- ^ Hans Dieter Neuwinger (1996). African Ethnobotany: Poisons and Drugs : Chemistry, Pharmacology, Toxicology. CRC Press. p. 123. ISBN 9783826100772.
- ^ Menzies, J. R.; Paterson, S. J.; Duwiejua, M; Corbett, A. D. (1998). "Opioid activity of alkaloids extracted from Picralima nitida (fam. Apocynaceae)". European journal of pharmacology. 350 (1): 101–8. PMID 9683021.
- ^ Lewin, G; Le Ménez, P; Rolland, Y; Renouard, A; Giesen-Crouse, E (1992). "Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors". Journal of natural products. 55 (3): 380–4. PMID 1317407.
