TM-38837
From Wikipedia, the free encyclopedia
(Redirected from TM38837)
This article may rely excessively on sources too closely associated with the subject, potentially preventing the article from being verifiable and neutral. (April 2011) (Learn how and when to remove this template message) |
Clinical data | |
---|---|
ATC code | none |
Legal status | |
Legal status |
|
Identifiers | |
|
|
CAS Number | 1253641-65-4 |
PubChem (CID) | 49779607 |
ChemSpider | 29361353 |
Chemical and physical data | |
Formula | C30H25Cl2F3N4OS |
Molar mass | 617.51 g/mol |
3D model (Jmol) | Interactive image |
|
|
|
TM-38837 is a small molecule inverse agonist/antagonist of the CB1 cannabinoid receptor, with peripheral selectivity. It is being developed for the treatment of obesity and metabolic disorders by 7TM Pharma.[1] The company has announced phase I clinical trials.
TM-38837 is among the first of a new generation of cannabinoid receptor antagonist designed to avoid the central nervous system liabilities of the first generation CB1 receptor antagonists such as rimonabant.[2]
See also[edit]
References[edit]
- ^ https://web.archive.org/web/20110707065905/http://www.7tm.com/. Archived from the original on July 7, 2011. Retrieved January 18, 2011. Missing or empty
|title=
(help) - ^ Hung, M. S.; Chang, C. P.; Li, T. C.; Yeh, T. K.; Song, J. S.; Lin, Y.; Wu, C. H.; Kuo, P. C.; Amancha, P. K.; Wong, Y. C.; Hsiao, W. C.; Chao, Y. S.; Shia, K. S. (2010). "Discovery of 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a Potential Peripheral Cannabinoid-1 Receptor Inverse Agonist". ChemMedChem. 5 (9): 1439–1443. doi:10.1002/cmdc.201000246. PMID 20652930.
External links[edit]
This cannabinoid related article is a stub. You can help Wikipedia by expanding it. |