Nitecapone

Nitecapone
Systematic (IUPAC) name
	3-(3,4-dihydroxy-5-nitrobenzylidene)-2,4-pentanedione
Identifiers
CAS Number	116313-94-1
ATC code	None
PubChem	CID 5464105
ChemSpider	4576539
Chemical data
Formula	C12H11NO6
Molar mass	265.219 g/mol
3D model (Jmol)	Interactive image
	SMILES [O-][N+](=O)c1cc(\C=C(/C(=O)C)C(=O)C)cc(O)c1O ;
	InChI InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3 ; Key:UPMRZALMHVUCIN-UHFFFAOYSA-N ;

Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).^[1]^[2] It was patented as an antiparkinsonian agent but was never marketed.^[1]

References[edit]

^ ^a ^b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978-0-412-46630-4. Retrieved 20 May 2012.
^ Nissinen E, Lindén IB, Schultz E, Kaakkola S, Männistö PT, Pohto P (August 1988). "Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of Pharmacology. 153 (2-3): 263–9. doi:10.1016/0014-2999(88)90614-0. PMID 3181288.

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