AVN-101

AVN-101
Identifiers
	IUPAC name 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
ChemSpider	24643855;
ChEMBL	CHEMBL592752;
Chemical and physical data
Formula	C21H24N2
Molar mass	304.44 g·mol−1
3D model (Jmol)	Interactive image;
	SMILES Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C ;
	InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 ; Key:IBUHDDLETPJVGP-UHFFFAOYSA-N ;

AVN-101, a close structural analogue of latrepirdine, is a selective 5-HT₆ receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders.^[1]^[2]^[3] As of November 2013, it is in phase II clinical trials for these indications.^[2]^[3]^[4]

References[edit]

^ V. Ivachtchenko, Alexandre; A. Ivanenkov, Yan (2013). "Small Molecule 5-HT6R Ligands: A Comprehensive Insight into their Selectivity and Activity". Current Bioactive Compounds. 9 (1): 64–100. doi:10.2174/1573407211309010007. ISSN 1573-4072.
^ ^a ^b Griebel, Guy; Holmes, Andrew (2013). "50 years of hurdles and hope in anxiolytic drug discovery". Nature Reviews Drug Discovery. 12 (9): 667–687. doi:10.1038/nrd4075. ISSN 1474-1776. PMID 23989795.
^ ^a ^b Benhamú, Bellinda; Martín-Fontecha, Mar; Vázquez-Villa, Henar; Pardo, Leonardo; López-Rodríguez, María L. (2014). "Serotonin 5-HT6Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer's Disease". Journal of Medicinal Chemistry. 57 (17): 7160–7181. doi:10.1021/jm5003952. ISSN 0022-2623. PMID 24850589.
^ AdisInsight. "AVN 101". Retrieved 2015-06-10.

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Identifiers

IUPAC name 2,8-Dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
ChemSpider	24643855
ChEMBL	CHEMBL592752
Chemical and physical data
Formula	C₂₁H₂₄N₂
Molar mass	304.44 g·mol⁻¹
3D model (Jmol)	Interactive image
SMILES Cc1ccc2c(c1)c3c(n2CCc4ccccc4)CCN(C3)C
InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3 Key:IBUHDDLETPJVGP-UHFFFAOYSA-N